Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance, and discuss advancing approaches to overcoming this therapeutic challenge based on the most recent findings in the field. The book discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with microenvironment, disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. One chapter also discusses conceptually novel approaches to design and develop small molecule inhibitors to overcome drug resistance. This book provides a unique opportunity to the reader in understanding the fundamental causes of drug resistance and how different approaches are currently being applied to overcome this challenge. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in each chapter in depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies INDICE: 1. Introductory Chapter2. Tumor Metabolic Reprogramming in Therapeutic Resistance3. Development of novel antiandrogens to overcome castrate resistant prostate cancer4. Microenvironmental regulation of cancer response to therapy and therapy resistance5. Revisiting immunogenic cell death to overcome treatment resistance in cancer immunotherapy6. Preventing Phenotypic Plasticity in Cancer to Mitigate Therapy Resistance7. Overcoming drug resistance in cancer with targeted radionuclide therapy8. The PI3K pathway and chemotherapy resistance9. Targeting leukemia stem cells in T-cell acute lymphoblastic leukemia10. Escape from apoptosis: Anastasis as a potential mechanism of cancer drug resistance11. From genetic data and structures to drug development: new approaches to targeting Eph receptors12. Overcoming Therapeutic Resistance in Glioblastoma: a major clinical challenge

• ISBN: 978-0-12-821310-0
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 200
• Fecha Publicación: 01/02/2021
• Nº Volúmenes: 1
• Idioma: Inglés