Handbook on immunosenescence: basic understanding and clinical applications

This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book thereforeconsiders methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge? The first comprehensive handbook on immunosenescence First to treat in one volume all the aspects of immunosenescence Bridging bench research and clinical applications Written by internationally recognised people in the field of immunosenescence Useful for anti-aging research and clinic INDICE: 1. Immunosenescence.- 2. Methods and models for studying immunosenescence.- 3. Cellular immunosenescence. 3.1 T cells. 3.2. B cells. 3.3 Neutrophils. 3.4 Antigen presenting cells. 3.5 NK and NKT cells. 3.6. Stem cells. 3.7. Genetics.- 4. Mechanisms4.1. Receptors and signal transduction. 4.2 Mitochondria. 4.3 Proteasome. 4.4 Cytokines. 4.5 Neuro-endocrine-immune Network. 4.6 Thymus. 4.7. Inflammation.- 5. Clinical relevance in disease states. 5.1 Infection. 5.2 Autoimmunity. 5.3 Cancer. 5.4 Metabolic syndrome. 5.5. Neurodegenerative diseases. 5.6 Frailty. 5.7. Osteoporosis.- 6. Modulation. 6.1 Nutrition. 6.2. Lipids. 6.3. Vaccination. 6.4. Can interventions to influence immunosenescence succeed? Subject Index.

• ISBN: 978-1-4020-9062-2
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 1654
• Fecha Publicación: 01/02/2009
• Nº Volúmenes: 1
• Idioma: Inglés