Stem Cell Therapy: Practical Considerations

Stem Cell Therapy: Practical Considerations

Gabr, Hala
El-Kheir, Wael Abo

130,00 €(IVA inc.)

Stem cell therapy is a fast-growing field of medicine with remarkable prospects in a broad spectrum of diseases. Stem Cell Therapy: Practical Considerations addresses the biological properties of stem cells, mechanisms of action; as well as actual therapeutic decisions such as cell type, source, dose, manipulation, and route of injection. After discussing all this data, the book will illustrate how to travel through the idea from abstract question to laboratory experiment, animal experiment and then on to design a clinical trial throughout all its phases. Written for scientists and postgraduate students in the field of stem cell research and therapy. The authors will cover practical therapeutic issues they have long experienced in the field. Provides readers the basics and clinical practice of stem cell therapyHelps to debunk controversies regarding data fabrication in the fieldGuides the reader through the mechanisms of the regenerative function of stem cells; as well as the therapeutic decisions such as delivery route, delivery timing, cell doses, and follow-up INDICE: I. Historical Aspects SC applications extending from hematological reconstitution to whole-body regeneration II. Basic Biology A. Anatomical considerations Bone Marrow Anatomy The Niche B. Definition and properties 1. Pluripotency 2. Self-renewal 3. Proliferation 4. Differentiation 5. Plasticity 6. Homing and Engraftment C. Classification D. Sources III. Mechanisms of SC-related regeneration 1. Transdifferentiation 2. Angiogenesis 3. Stimulation of endogenous stem cells 4. Paracrine function 5. Cell Fusion 6. Exosome mediated functions IV. Debates in SC therapy A. ES vs Adult Cell Type B. BM vs PB Cell Source C. To differentiate or not to differentiate, this is the question D. To expand or not E. To isolate or not V. Laboratory Decision A. Methods of SC isolation B. Ex-vivo expansion C. Basic concepts in differentiation D. Delivery routes VI. How to design a stem cell therapy trial

  • ISBN: 978-0-12-821569-2
  • Editorial: Academic Press
  • Encuadernacion: Rústica
  • Páginas: 275
  • Fecha Publicación: 01/09/2020
  • Nº Volúmenes: 1
  • Idioma: Inglés