This volume covers all aspects of endoplasmic reticulum (ER) biology. With its multiple cellular functions including ion storage as well protein folding, trafficking and secretion, the regulation of homeostasis within the ER is crucial to organismal health. Dysregulation of ER homeostasis plays an important role in the induction of autophagy, the onset of adaptive immune responses and can lead to ER-related pathologies. Harnessing the proimmunogenic signaling that is governed by the ER underpins anticancer immunotherapy. Summarizes ER-related pathologiesGives report on immunological aspects of ER-stress Brings the links between ER homeostasis and autophagy INDICE: 1. DAMP emission upon ER stress 2. Protein misfolding disorders 3. Type I interferon response and ER stress 4. ER and autophagosome biogenesis 5. Mitochondria-associated membranes 6. ER calcium signaling in excitable cells 7. ER in viral infection
- ISBN: 978-0-12-819744-8
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 277
- Fecha Publicación: 15/01/2020
- Nº Volúmenes: 1
- Idioma: Inglés