Tumor Immunology and Immunotherapy - Integrated Methods Part B

Tumor Immunology and Immunotherapy - Integrated Methods Part B, Volume 636 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this update include Quantification methods of Transforming Growth Factor beta (TGF??) activity in the setting of cancer immunotherapy, Decoding cancer cell death-driven immune cell recruitment: An in vivo method for site-of-vaccination analyses, Tracking and interrogating tissue-resident and recruited microglia in brain tumors, Metabolomics and lipidomics of the tumor microenvironment, Monitoring abscopal responses to radiation in mice, and much more. Provides an array of authors who are authorities in the field Presents comprehensiveness coverage of the topics Includes a broad level of detail and in-depth coverage INDICE: 1. Quantification methods of Transforming Growth Factor beta (TGF??) activity in the setting of cancer immunotherapy 2. Decoding cancer cell death-driven immune cell recruitment: An in vivo method for site-of-vaccination analyses 3. Tracking and interrogating tissue-resident and recruited microglia in brain tumors 4. Metabolomics and lipidomics of the tumor microenvironment 5. Monitoring abscopal responses to radiation in mice 6. Methods to assess immunological antitumor effects of adenosine pathway manipulation 7. Methods to assess anticancer immune responses in orthotopic bladder carcinomas 8. Quantitative Evaluation of Tumor-specific T Cells in Tumors and Lymphoid Tissues 9. RNA interference screening methods to identify proliferation determinants and mechanisms of resistance to immune attack 10. An altered miTRAP method for miRNA affinity purification with its pros and cons 11. Identification of immunomodulatory RNA-binding proteins in tumors 12. Neoantigen prediction from genomic and transcriptomic data 13. Computational methods in systematic and integrative analyses of tumor immune landscape 14. Modular analysis to evaluate immunotherapy-induced perturbations 15. Methods to implement oncolytic virotherapy in preclinical models 16. Production and Use of Adeno-Associated Virus Vectors as Tools for Cancer Immunotherapy 17. Modulation of the tumor microenvironment with an oncolytic adenovirus for effective T-cell therapy and Checkpoint Inhibition 18. Genetic modification of oncolytic viruses to enhance antitumor immunity 19. Techniques for the generation of humanized models for immuno-oncology 20. CRISPR technology for immuno-oncology applications

• ISBN: 978-0-12-820667-6
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 412
• Fecha Publicación: 01/04/2020
• Nº Volúmenes: 1
• Idioma: Inglés