The Science, Etiology and Mechanobiology of Diabetes and its Complications

The mechanobiology of diabetes and its complications is the most comprehensive synthesis of contemporary global research on diabetes providing a novel and unique mechanobiological perspective - addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. It provides a unique approach to communicating the diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycaemia.  Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here. Faculty and graduate students as well as medical practitioners can use this volume for learning about the latest achievements and great promises that mechanobiology brings in to biomedical research of diabetes, including in aspects of new treatment and care pathways.  Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processesDescribes the state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycaemia and diabetesExplores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry INDICE: Part I Mechanobiology of diabetes: Basic science aspects at the microscale 1. Effects of chronic high-glucose exposures and mechanical loads on signalling pathways in fibroblasts and adipocytes 2. Review of mathematical modelling of cell dynamics under diabetic conditions 3. Effects of hyperglycaemia and mechanical stimulations on differentiation fate of mesenchymal stem cells 4. Cell-extracellular matrix mechanotransduction phenomena and collagen network changes in connective diabetic tissues 5. Leukocyte responses to shear stress in diabesity-related cardiovascular diseases 6. Mechanotransduction of the myogenic response in diabetic tissues 7. Potential mechanobiological links between diabetes and osteoarthritis Part II The pathomechanics of structure-function relationships in diabetic tissues and its consequences on diabetic tissue physiology 8. How diabetes impacts the biophysical and biomechanical properties of connective tissues 9. Optical coherence tomography to determine and visualize pathological skin structure changes caused by diabetes 10. The impact of diabetes on skin barrier properties 11. The influence of diabetes on structure and function of heart valve and blood vessel wall tissues 12. Corneal tissue changes in diabetes and their impact on corneal tissue function and vision 13. The impact of diabetes and diabetic neuropathy on plantar tissue structure, foot and gait function Part III Technological innovations and bioengineering advancements in management, repair and replacement of tissues and body systems damaged by diabetes 14. Contemporary considerations in plastic surgery of tissues affected by diabetes 15. Artificial tactile systems and smart fabrics to substitute for nerve-end damage caused by diabetes 16. Novel smart insole technologies to compensate for diabetic peripheral neuropathy damage 17. Novel cell engineering interventions to treat retinal tissue damage caused by diabetes 18. Corrections of neuromuscular function impairments caused by diabetes by means of robotic wearable devices

• ISBN: 978-0-12-821070-3
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 400
• Fecha Publicación: 01/02/2021
• Nº Volúmenes: 1
• Idioma: Inglés