The scope of this book was preempted and precipitated by the pioneering studies of Ussing and co-workers. The first phase of the phenomenological description of the cell as a black box has been followed by studies of cellular mechanisms, the interplay of the different transport components, and the mechanisms of regulation which will be covered in the individual chapters. For the individual epithelia transport schemes that have been proposed, I think it is appropriate to take pause and search for elements common to several epithelia. This aspect triggered the common theme idea for this book, and in fact the various chapters emphasize that the functional transporter components, expressed in thevarious epithelia, are not infinite in number, but they occur in epithelia which are separated in evolution by several hundred million years. The diversityof organisms from invertebrate to vertebrate telescopes possible evolutionarytrends in a given transport process The diversity of transporters in various animal epithelia inductively traces the adaptive response of the specific animal in regards to its environmental pressures Speculation as to how epithelial transporters came to exist after the 'Big Bang' created our universe INDICE: Active, electrogenic chloride absorption in invertebrate foregut.-Sulfate transport in lobster hepatopancreas.- Heavy metal transport in lobster lysosomes.- H+-ATPase and K+ /H + antiporter constitute a K+ pump in lepidopteran midgut.- Genomic regulation of amino acid transport.- CFTR, a transporter in health and disease.- Chloride transport in the vertebrate intestine.- Sulfate and phosphate transport in intestinal and renal epithelia.- Amino acid transporters in mammalian epithelia.- Sugar transport in vertebrate epithelia.- Renal acid/base regulation via ammonia transport in mammals.- Renal acid/base control: K+ /H +-ATPase contribution.
- ISBN: 978-1-60327-228-5
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 770
- Fecha Publicación: 01/12/2009
- Nº Volúmenes: 1
- Idioma: Inglés