Biometals in Autism Spectrum Disorders will be the first to focus on trace metals and autism. Compared to other references examining ASDs or metallomics, a focused presentation of the findings of abnormal metal homeostasis in ASD has not yet come to be. This book provides for readers an overview of current findings on trace metal biology with respect to its role in ASD etiology and discusses how abnormal trace metal biology may be a common factor of several genetic and non-genetic causes of ASDs considered unrelated in the past. This will open new vistas for the development of new therapies based on targeted manipulation of trace metal homeostasis and generate awareness that trace metal levels during pregnancy must be tightly monitored. Reviews the role of trace metals in brain developmentSummarizes research linking trace metals and autismExplores heterogenous phenotypes as a factor of genetic and non-genetic factorsIncludes animal and human stem researchContains many diagrams, tables, and flow chartsProposes future therapies based on biometal homeostasis INDICE: 1. Introduction to MEtallomics: The Science of Biometals 2. Measuring Biometlas 3. The history of metals in Autism Spectrum Disorders 4. Essential trace metals and their function in brain development 5. Non-essential metals and their brain pathology 6. Biometals and nutrition in Autism Spectrum Disorders 7. Linking trace metal abnormalities to Autism - insights from epidemiological studies 8. The specific role of zinc in Autism Spectrum Disorder 9. Animal models for trace metal abnormalities - links to Autism 10. Animal models for Autism - links to biometals abnormalities 11. Human stem cell models linking biometals abnormalities and Autism 12. Extracerevral biometlas in Autism Spectrum Disroders: the gut-brain axis 13. Biometal homeostasis as therapeutic strategy in Autism Spectrum Disorders 14. Future perspectives: Autism, a disorder of biometal imbalance?
- ISBN: 978-0-12-821132-8
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 222
- Fecha Publicación: 20/07/2020
- Nº Volúmenes: 1
- Idioma: Inglés