Multivariate (MV) analysis of the multi-component analytical profiles of carefully collected biofluid and/or tissue biopsy specimens provides a 'fingerprint' of their biomolecular/metabolic status. This exemplary new book applications of these techniques in the areas of drug therapy and toxicology, cancer, obesity, diabetes and cardiovascular, infectious, inflammatory and oral diseases are outlined in detail, with particular reference to cautionary measures whichmust be applied to the diagnosis and classification of these conditions or physiological criteria. Of particular interest are the focused on experimental design and 'rights' and wrongs' of the techniques commonly applied by researchers, and the very recent development of powerful 'Pattern Recognition' techniques. INDICE: Preface; Introduction to the Applications of Chemometric Techniques in 'Omics' Research; Common Pitfalls, Misconceptions and 'Rights and Wrongs'in Metabolomics Research; Experimental Design: Sample Collection, Sample Size, Power Calculations, Molecular Analysis-Of-Variance etc.; Exploratory Data Analysis and Pattern Recognition Techniques: State-of-the-Art; Applications to the Diagnosis and Prognosis of Diseases; Early Disease Diagnosis; Mass Spectrometric Evaluations of Microbial, Plant and Mammalian Metabolomes; Biomarkers for Cancer; Multiple Biomarkers in Molecular Oncology; Mass Spectrometric-Based Metabolomics in Breast Cancer Diagnosis; Obesity; Type II Diabetes; Vascular Injury; Metabolomic Approaches to the Investigation of Cardiovascular Diseases;Disease-Related Urinary Metabolic Patterns for Osteoarthritis; Infectious Diseases; 1H NMR-Linked Metabonomics in the Oral Sciences: Evaluations of Oral Health Status and Dentifrice Product Intervention; Testing and Evaluation of Oral Health Care Products; Drug Toxicity; Toxicogenomics; Drug-Induced Hepatotoxicity; Drug Discovery; Index
- ISBN: 978-1-84973-163-8
- Editorial: Royal Society of Chemistry
- Encuadernacion: Cartoné
- Páginas: 384
- Fecha Publicación: 30/09/2012
- Nº Volúmenes: 1
- Idioma: Inglés