Nutraceuticals: Efficacy, Safety and Toxicity

Nutraceuticals: Efficacy, Safety and Toxicity, Second Edition brings together everything that is currently known about nutraceuticals, and their potential toxic effects, from those scientists at the forefront of their study. Readers are introduced to nutraceuticals, herbal medicines, Ayurvedic medicines, prebiotics, probiotics, and adaptogens, their use and specific applications. This essential reference then discusses the mechanism of action for the judicious use of these nutraceuticals, and the best tools for their evaluation, before detailing the safety and toxicity of nutraceuticals, and interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered. Completely revised and updated, Nutraceuticals: Efficacy, Safety and Toxicity, Second Edition provides toxicologists, pharmacologists, pharmaceutical scientists, and those interested in medicinal plants and natural products with a comprehensive overview of the most effective tools to evaluate the safety and toxicity of nutraceuticals, prebiotics, probiotics, and alternative medicines. Completed revised and updates, includes new chapters on the impact of nutraceuticals and various disease states such as diabetes, ophthalmic, and dermal diseasesGrants an overview of the current state-of-the-science of nutraceuticals, for their use and applications, and known adverse effectsProvides effective tools to evaluate the potential toxicity of any nutraceuticalIncludes details of regulatory issues, written by international experts INDICE: Section-I APPLICATIONS OF NUTRACEUTICALS IN COMMON DISEASES AND DISORDERS 1. Nutraceuticals in CNS Diseases: Potential Mechanisms of Neuroprotection 2. Prevention of Neurodegenerative Disorders and aging by Nutraceuticals 3. Cognitive Effects of Nutraceuticals 4. Nutraceuticals in Anxiety and Stress 5. Nutraceuticals in Cardiovascular Diseases 6. Nutraceuticals for Diabetes and Metabolic Syndrome 7. Nutraceuticals in Respiratory Disorders 8. Nutraceuticals in Hepatic Diseases 9. Nutraceuticals in Renal Diseases 10. Nutraceuticals in Gastrointestinal Disorders 11. Nutraceuticals in Reproductive and Developmental Disorders 12. Nutraceuticals in Ophthalmic Diseases 13. Nutraceuticals in Dermal Diseases 14. Nutraceuticals in Arthritis 15. Nutraceuticals in Sports Activities and Fatigue 16. Nutraceuticals as Adaptogens: Their Role in Health and Disease 17. Nutraceuticals for weight loss 18. Nutraceuticals in Cancer Prevention 19. Application of Nano? Nutraceuticals in Medicine Section-II MODELS AND MECHANISMS IN EVALUATION OF NUTRACEUTICALS 20. The Biology of Nutrients: Genetic and Molecular Principles 21. Genomic and Proteomic Mechanisms and Models in Toxicity and Safety Evaluation of Nutraceuticals 22. Gene Expression Profiling in Evaluating the Safety and Toxicity of Nutraceuticals 23. Target Identification and Polypharmacology of Nutraceuticals 24. Mechanistic Network Models in Safety and Toxicity Evaluation of Nutraceuticals 25. Noninvasive In Vivo Optical Imaging Models for Safety and Toxicity Testing 26. Flow Cytometry and Light Scattering Technique in Evaluation of Nutraceuticals 27. Zebrafish Model for Safety and Toxicity Testing of Nutraceuticals 28. Caenorhabditis elegans: A Model Organism for Nutraceutical Safety and Toxicity Evaluation 29. Alternative In Vitro Models for Safety and Toxicity Evaluation of Nutraceuticals 30. Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals 31. Oxidative Stress and Excitotoxicity: Antioxidants from Nutraceuticals 32. Impact of Nutraceuticals on Drug Metabolizing Enzymes Section-III COMMON NUTRACEUTICALS 33. Caffeine: An Evaluation of the Safety Database 34. Resveratrol: Multiple Activities on the Biological Functionality of the Cell 35. Melatonin: A Safe Nutraceutical and Clinical Agent 36. Curcumin 37. Fenugreek: Multiple Health Benefits 38. Cannabis sativa and Hemp 39. Safety and Toxicity of Cannabidiol and Other Cannabinoids in Nutraceuticals and Wellness Products 40. St. John's Wort 41. Green Tea Extract 42. Green Coffee Bean 43. Quercetin 44. Chamomile 45. Aloe vera 46. Propolis 47. Honey as a Nutraceutical to Nutraceuticals for Bees 48. Ginkgo biloba 49. Chinese Ginseng 50. Ashwagandha: Multiple Health Benefits 51. Astaxanthin: Health Benefits and Toxicity 52. Thymoquinone 53. Glucosinolates 54. Organosulfur Compounds as Nutraceuticals 55. Arginine and Citrulline as Nutraceuticals: Efficacy and Safety in Diseases 56. Neem Extract 57. Spirulina 58. Garcinia cambogia 59. TPGS and its Nutraceutical Application 60. Transferrins 61. Glutamine 62. Placenta as a Dietary Supplement 63. Chitosan and derivatives Section-IV PREBIOTICS AND PROBIOTICS 64. Prebiotics: Safety and Toxicity Considerations 65. Probiotics: Safety and Toxicity Considerations 66. Synbiotics: Safety and Toxicity Considerations Section-V NUTRACEUTICALS IN VETERINARY MEDICINE 67. Nutraceuticals in animal health and diseases Section-VI TOXICITY AND TOXIC INTERACTIONS 68. Toxic Contamination of Nutraceuticals and Food Ingredients 69. Nutraceuticals and Adverse Outcome Pathways 70. Interactions between Nutraceuticals/Nutrients and Therapeutic Drugs 71. Assessment of Genotoxic Effects of Selected Herbal Dietary Supplements Section-VII REGULATORY ASPECTS 72. Regulatory Assessment of Dietary Ingredients and Nutraceuticals in North America 73. Evaluation and Regulation of Food Supplements: European Perspective 74. Regulatory Aspects of Nutraceuticals: An Indian Perspective 75. Regulatory Aspects of Nutraceuticals: Chinese Perspective 76. Uses and Regulations of Nutraceuticals in Australia and New Zealand 77. Regulatory Aspects of Nutraceuticals: Japanese Perspective 78. Nutraceuticals: Turkish Perspective

• ISBN: 978-0-12-821038-3
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 1050
• Fecha Publicación: 01/02/2021
• Nº Volúmenes: 1
• Idioma: Inglés