Cancer-Leading Proteases: Structures, Functions, and Inhibition

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancerDiscusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkersCovers a wide range of cancers and provides detailed discussions on protease examples INDICE: 1. Proteases and Their Biological Roles and Mechanism of Action2. Specificity and Diversity in Proteases3. Potential Roles of Protease Inhibitors in Cancer Progression4. Serine Proteases in Ovarian Cancer5. Aspartic Proteases as Potential Drug Targets for Anticancer Drug Development6. Design and Development of Serine Proteases Acting against Prostate Cancer7. Urokinase and Colorectal Carcinoma: Studies on Mechanism and Inhibition8. Overexpression of Cystein Proteases and Colorectal Carcinoma9. Studies on Cystein Proteases and Their Inhibitors for Anti-cancer Drug Design10. Gelatinases and Anticancer Drug Development11. HCV NS3 Serine Protease as a Drug Target for Development of Drugs Against Liver Cancer12. Molecular Imaging of Proteases in Cancer

• ISBN: 978-0-12-818168-3
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 526
• Fecha Publicación: 03/02/2020
• Nº Volúmenes: 1
• Idioma: Inglés