Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. Viral Proteases and Their Inhibitors investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. This book provides individual descriptions of each virus, details the structure and function of viral proteases, discusses the design and development of inhibitors, and analyzes the structure-activity relationships of inhibitors. It will be helpful to biochemists, virologists and to those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus life cycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral proteasePresents an in depth view of the structure and function of viral proteases INDICE: 1. Fundamentals of Viruses and Their Proteases Anjana Sharma and Satya P. Gupta 2. Design and Development of Some Viral Protease Inhibitors by QSAR and Molecular Modeling Studies Noha Saleh Hanan Elhaes and Medhat Ibrahim 3. Advances in Studies on Adenovirus Proteases and Their Inhibitors Satya P. Gupta Basheerulla Shaik and Y. S. Prabhakar 4. Alpha-virus Nonstructural Proteases and Their Inhibitors Akalabya Bissoyi, Subrat Kumar Pattanayak Arindam Bit Ashish Patel, Abhishek 5. Structure and Function of Alphavirus Protease Shailly Tomar and Megha Aggarwal 6. Flavivirus Protease: An Antiviral Target Shailly Tomar, Rajat Mudgal and Benazir Fatma 7. Flavivirus NSB/NS3 Protease: Structure, Function, and Inhibition Zhong Li Jing Zhang Hongmin Li 8. Design and Development of HCV NS5B Polymerase Inhibitors Debasis Das 9. Studies on HIV-1 Protease and its Inhibitors Sonal Dubey 10. Studies on Picornaviral Proteases and Their Inhibitors Vaishali M. Patil and Satya P. Gupta 11. Structural Insight into the Viral 3C-like Protease inhibitors: Comparative SAR/QSAR Approaches Nilanjan Adhikari Sandip Kumar Baidya Achintya Saha, Tarun Jha 12. Herpesvirus Proteases: Structure, Function, and Inhibition Kriti Kashyap and Rita Kakkar 13. Design and Development of Inhibitors of Herpes Viral Proteases and Their SAR and QSAR Dimitra Hadjipavlou-Litina and Satya P Gupta 14. Delicate Dance in Treating Hepatitis C Infections and Overcoming Resistance Dolly A. Parasrampuria
- ISBN: 978-0-12-809712-0
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 496
- Fecha Publicación: 06/07/2017
- Nº Volúmenes: 1
- Idioma: Inglés