Evaluation of drug candidates for preclinical development: pharmacokinetics, metabolism, pharmaceutics, and toxicology

This book serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well-suited for those in small- to mid-sized pharmaceutical companies, where there may not be entrenched infrastructure for evaluating the developability of new chemicalentities. The book also aids academic researchers and students concerned withthe practical aspects related to the evaluation of drug developability. Coverage includes sections on: pharmacokinetics and drug metabolism, integration ofpharmaceutical development, and predictive safety assessment. Chapters include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, preclinical safety assessment, and toxicology and toxicokinetics. This book provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discoveryand development. INDICE: Preface. Contributors. 1. Introduction. 2. Pharmacokinetics in preclinical drug development: an overview. 3. The role of membrane transporters in drug disposition. 4. Cytochrome p450: structure, function, and application in drug discovery and development. 5. The role of drug metabolism and metabolite identification in drug discovery. 6. Protein binding in drug discovery and development. 7. Prediction of the pharmacokinetics in humans. 8. pharmaceutics developability assessment. 9. Safety assessment in drug discovery. 10. Assessment of strategies utilized to minimize the potential for induction of acquiredlong qt syndrome and torsade de pointes. Index.

• ISBN: 978-0-470-04491-9
• Editorial: Wiley
• Encuadernacion: Cartoné
• Páginas: 289
• Fecha Publicación: 28/01/2010
• Nº Volúmenes: 1
• Idioma: Inglés