New Models of the Cell Nucleus: Crowding, Entropic Forces, Phase Separation, and Fractals

International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2012: 4.973. Ideas from the fields of biophysics, physical chemistry, of polymer and colloid, and soft matter science have helped clarify the structure and functions of the cell nucleus. The development of powerful methods for modeling conformations and interactions of macromolecules has also contributed. The book aims to encourage cell and molecular biologists to become more familiar with and understand these new concepts and methods, and the crucial contributions they are making to our perception of the nucleus. This is the first volume to present a comprehensive review of New Models of the Cell Nucleus. INDICE: The Nuclear PhysiqueThoru PedersonThe Crowded NucleusRonald HancockCrowding in Polymer-Nanoparticle MixturesAlan R. DentonCrowding-Induced Formation and Structural Alteration of Nuclear Compartments: Insights from Computer SimulationsEun Jin Cho, Igal Szleifer and Jun Soo KimPhase Separation as a Possible Means of Nuclear CompartmentalizationWilliam M. Aumiller, Jr, Bradley W. Davis and Christine D. KeatingFormation of Multi-Protein Assemblies in the Nucleus: The Spindle Assembly Checkpoint (SAC)Victor M. Bolanos-GarciaCharacteristic Behavior of Crowding Macromolecules Confined in Cell-Sized DropletsMiho Yanagisawa, Takahiro Sakaue and Kenichi YoshikawaNon-Canonical Structures and their Thermodynamics of DNA and RNA Under Molecular Crowding: Beyond the Watson-Crick Double HelixNaoki SugimotoComputational Models of Large-Scale Genome ArchitectureAngelo Rosa and Christophe ZimmerHow Chromatin Looping and Nuclear Envelope Attachment Affect Genome Organization in Eukaryotic Cell NucleiHansjoerg Jerabek and Dieter W. HeermannCrowding, Diffusion, and Biochemical ReactionsMatthias WeissImportance of Crowding in Signaling, Genetic, and Metabolic NetworksPieter Rein ten Wolde and Andrew MuglerRelevance and Limitations of Crowding, Fractal, and Polymer Models to Describe Nuclear ArchitectureSébastien Huet, Christophe Lavelle, Hubert Ranchon, Pascal Carrivain, Jean-Marc Victor and Aurélien Bancaud

• ISBN: 978-0-12-800046-5
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 548
• Fecha Publicación: 26/02/2014
• Nº Volúmenes: 1
• Idioma: Inglés