Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals

Fluorine in Life Sciences, the fourth volume in Alain Tressaud's Progress in Fluorine Science Series, presents a critical, multidisciplinary overview on the contributions of fluorinated products to solve important global issues in various life science fields, particularly in medicinal chemistry, molecular imaging techniques, and agriculture. Edited by recognized experts, the book provides unique coverage of the wide ranging uses and implications of fluorine and fluorinated compounds. Featuring contributions from top specialists from around the world, the work will contain valuable information on: Medicinal monitoring and diagnosis; 19F MRI in medicine and for in vivo cell tracking; 18F-labeled radiopharmaceuticals; brain imaging and neurology; risk assessment of reactive metabolites in drug discovery; fluorine effects for drug design; pharmaceutical industry; photodynamic cancer therapy; and agricultural aspects (fluorine in modern crop protection, biodegradation vs. biotransformation). The 'Progress in Fluorine Science' series covers emerging trends and research in the area. Edited by Alain Tressaud, immediate past Chair and founder of the CNRS French Fluorine Network, each book in the collection also includes the work of highly-respected volume editors and contributors from both academia and industry, to bring valuable and varied content to this active field. Covers a wide range of topics from organic and physical chemistry, to pharmaceuticals and agrochemicals, and also medical diagnosticsDescribes major modern syntheses and unique reaction mechanisms yielding fluorine compounds in these diverse life science settingsEdited and contributed by a wealth of global experts, Fluorine in Life Sciences is the fourth volume in Alain Tressaud's Progress in Fluorine Science Series INDICE: Medicinal Aspects 1. Review on fluorine in Medicinal Chemistry 2. Microbial fluorination/18F-labeling 3. Risk Assessment of reactive metabolites in drug discovery 4. Bioisosteres in Drug Design 5. Fluorinated Mechanism-Based Inhibitors 6. Fluorine in the Pharmaceutical Industry / Bio-relevant Fluorinated N-Heterocycles 7. Polyfluorinated groups in Medicinal Chemistry 8. Application of Fluorine in Med Medicinal Chemistry 9. Physico-Chemical Properties and Biological Activity Of Fluorinated Compounds 10. Fluorinated GABA Analogues 11. Fluorinated Amino Acids In Protein Analytics, Photodynamic Cancer Therapy; Advanced Building Blocks for Drug Discovery 12. Fluorine effects in Drug Design 13. Hydrogen bonding in Drug Discovery / Fluorine local environment: from screening to drug design 14. Fluorosugars as Inhibitors of Bacterial Enzymes 15. Fluorinated Antibiotics 16. Antiimflamatory And Antimicrobial Agents 17. Late Stage Fluorination Applied In Drug Discovery 18. Fluorine in Drug Design (Anisols) Agricultural Aspects 19. Fluorine in Modern Crop Protection 20. Alpha,alpha-Difluorosulfonylisoxazoline Herbicides 21. Value of Fluorine in Agriculture 22. Biodegradation vs. Biotransformation of Fluorosubstituted Aromatics (agro-chemicals) Molecular Imaging Aspects 23. 19F MRI in medicine 24. 19F MRI for in vivo Cell Tracking 25. 18F 26. PET, Medical Imaging, Radiotracers 27. Integrin receptor imaging 28. Brain imaging, Neurology, 18F metabolite analysis 29. 18F-labeled Radiopharmaceuticals; Current Status of F-18-Trifluoroborate- and F-18-SiFA-Based Radiopharmaceuticals in PET 30. 18F-PET in Neuroimaging Bioorthogonal labelling of medicinally relevant structures

• ISBN: 978-0-12-812733-9
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 500
• Fecha Publicación: 01/03/2018
• Nº Volúmenes: 1
• Idioma: Inglés