Overcoming Obstacles in Drug Discovery and Development: Surmounting the Insurmountable

Overcoming Obstacles in Drug Discovery and Development: Surmounting the Insurmountable uses real-world case studies to illustrate how critical thinking and problem-solving skills are applied and necessary in the discovery and development of drugs. The book shows how the development of critical thinking to overcome issues plays an essential role in scientific and professional expertise. As addressing critical, unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills, this book is an ideal training manual on how to overcome obstacles.  It will be essential to young scientists who want to develop the skills to successfully face challenges, learn from their mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from case studies of successful and unsuccessful drug development Provides real-world case studies in drug discovery and the development of drugs Illustrates the use of critical thinking and problem-solving in approaching preclinical and clinical problems in drug discovery and development Analyzes examples of successes and failures in drug discovery and development that have not previously been reported INDICE: 1. Learning to think critically 2. Making the right decision 3. The drug discovery and development process (general) How are modern technologies developed and applied to drug discovery and development? 4.Human genome 5. High throughput screening 6. Structure-based drug design 7. Modern chemical synthesis 8. Antibody therapy 9. Discovery toxicology 10. Modern drug metabolism and pharmacokinetics 11. Modern pharmaceutics 12. Translational medicine 13. Biotechnology in general Drug discovery and development case study 14. Atorvastatin (how the 3rd statin became the best in class) 15. Apixaban (how distribution selectivity led to the discovery of apixaban) 16. Saxagliptin (how to solve animal specific toxicity issues) 17. Sustiva (how to solve animal specific toxicity issues) 18. Empagliflozin (drug degradation issue for carcinogenicity) 19. Tolfacitinib (Jak kinase inhibitor) 20. Dasatinib (discovery example for new indications) 21. Crizotinib (translational medicine example for a new indication) 22. Ipilimumab (CTLA4, 1st immune-oncology) 23. Nivolumab or pembrolizumab (PD-1) 24. Artemisinin (creative thinking to discover Artemisinin, Nobel Prize winning case) 25. Imatinib (1st TKI) 26. Deutetrabenazine (1st deuterium drug) 27. Esmolol (soft drug design) 28. Troglitazone (withdrawn from the  market) 29. Solanezumab (failed in phase III) 30. Fasiglifam (failed in phase III) Conclusion 31. How to apply lessons learned from the case studies in drug discovery and development

• ISBN: 978-0-12-817134-9
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 500
• Fecha Publicación: 01/10/2022
• Nº Volúmenes: 1
• Idioma: Inglés