The Neurobiology of Aging and Alzheimer Disease in Down Syndrome

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. Discusses the complexities involved with aging and Alzheimer's disease in Down syndrome Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research INDICE: 1. Introduction 2. Alzheimer's neuropathology in Down syndrome: From gestation to old age 3. The contribution of inflammation to Alzheimer's disease in Down syndrome 4. The role of cerebrovascular disease in aging and Alzheimer's disease among people with Down syndrome 5. Oxidative stress and mTOR in Down syndrome brain: Link to Alzheimer's dysmetabolism, neuropathology, and possible therapies 6. Fluid biomarkers for Alzheimer's disease in Down syndrome: Current status and novel trends 7. Proteomic and metabolomic biomarkers of Alzheimer's disease: Opportunities to advance precision medicine and clinical trials 8. Magnetic resonance imaging biomarkers for cognitive decline in Down syndrome 9. PET imaging in Down syndrome and Alzheimer's disease 10. Genetics of Alzheimer's disease in adults with Down syndrome 11. Co-occurring medical conditions in aging adults with Down syndrome 12. Sleep in aging adults with Down syndrome and its association with Alzheimer's disease 13. Contributions of the neurological examination to the diagnosis of dementia in Down syndrome 14. Psychiatric issues in aging and dementia 15. Cognitive profile of aging and dementia 16. Clinical trials for Alzheimer's disease in Down syndrome 17. Future directions Index

• ISBN: 978-0-12-818845-3
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 352
• Fecha Publicación: 27/08/2021
• Nº Volúmenes: 1
• Idioma: Inglés