The first three editions of this acclaimed book presented a much–needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up–to–date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. New contributors reflecting broader international authorship and even greater expertise Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date Now produced in full color for enhanced clarity Covers how molecular genetic data (PCR–based and sequencing information) are collated with the cytogenetic data where pertinent Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible INDICE: Contributors vii .Preface to the Fourth Edition ix .1 How it all began: cancer cytogenetics before sequencing 1Felix Mitelman and Sverre Heim .2 Cytogenetic methods 11David Gisselsson .3 Cytogenetic nomenclature 19Sverre Heim and Felix Mitelman .4 Nonrandom chromosome abnormalities in cancer: an overview 26Sverre Heim and Felix Mitelman .5 From chromosomes to genes: searching for pathogenetic fusions in cancer 42Ioannis Panagopoulos .6 Acute myeloid leukemia 62Bertil Johansson and Christine J. Harrison .7 Myelodysplastic syndromes 126Harold J. Olney and Michelle M. Le Beau .8 Chronic myeloid leukemia 153Thoas Fioretos .9 Chronic myeloproliferative neoplasms 175Peter Vandenberghe and Lucienne Michaux .10 Acute lymphoblastic leukemia 198Christine J. Harrison and Bertil Johansson .11 Mature B ] and T ]cell neoplasms and Hodgkin lymphoma 252Reiner Siebert and Sietse M. Aukema .12 Tumors of the upper aerodigestive tract 332Susanne M. Gollin .13 Tumors of the lung 361Penny Nymark, Eeva Kettunen and Sakari Knuutila .14 Tumors of the digestive tract 373Georgia Bardi and Sverre Heim .15 Tumors of the urinary tract 401Paola Dal Cin .16 Tumors of the breast 426Manuel R. Teixeira, Nikos Pandis and Sverre Heim .17 Tumors of the female genital organs 447Francesca Micci and Sverre Heim .18 Tumors of the male genital organs 481Manuel R. Teixeira and Sverre Heim .19 Tumors of endocrine glands 497Jörn Bullerdiek and David Gisselsson .20 Tumors of the nervous system 515Petter Brandal and Sverre Heim .21 Tumors of the eye 538Karen Sisley .22 Tumors of the skin 555Fredrik Mertens, Felix Mitelman and Sverre Heim .23 Tumors of bone 566Fredrik Mertens and Nils Mandahl .24 Soft tissue tumors 583Nils Mandahl and Fredrik Mertens .Index 615
- ISBN: 978-1-118-79553-8
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 648
- Fecha Publicación: 10/08/2015
- Nº Volúmenes: 1
- Idioma: Inglés