The synapse is a fundamental subcellular structure in the brain connecting neurons with each other. It transmits information from one neuron to another andis also involved in data processing and storage. The synapse is the site where neurons communicate with each other. A synapse is a small gap that physically separates neurons. This book is a comprehensive and detailed overview of thesynapse with emphasis on the glutamatergic synapse. Most chapters relate functional aspects to molecular mechanisms. This approach provides a sense of which mechanisms are characterized on both the functional and structural level andcan be considered firmly established. The chapters on basic physiological mechanisms are complemented by several chapters on the role of the synapse in pathological states. Deals directly with the different and specific aspects of synaptic function, unlike other available books which cover the fundamentals INDICE: From the contents Introduction. Transport and Storage of neurotransmitters. The neurotransmitter release machinery. Endocytic retrieval of synaptic vesicles. Linking the release machinery to neuronal excitation: SNARE binding to presynaptic Ca channels. Attaching the release machinery with the synaptic cleft matrix: Ca channel interaction with laminin. Connect the presynapticand postsynaptic site: neurexins, neuroligins, SynCAMs, and their intracellular binding partners. Structural and functional aspects of glutamate binding tothe AMPA receptor. The role of Stargazin and PSD95 in AMPA receptor accumulation at the postsynaptic site. Cell biology and biochemistry of the NMDA R. Physiology and Biophysics of Glutamate receptors. The regulators: postsynaptic targeting of protein kinases and phosphatases. The postsynaptic scaffolding proteins. The postsynaptic cytoskeleton. Synpatic plasticity: LTP and LTD. Development of the Synapse.
- ISBN: 978-0-387-77231-8
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 575
- Fecha Publicación: 01/04/2008
- Nº Volúmenes: 1
- Idioma: Inglés