Methods of Therapeutic Drug Monitoring including Pharmacogenetics, Second Edition, the 6th volume in the Handbook of Analytical Separations series, covers all aspects of drug monitoring including laboratory work, pharmacokinetic analysis, and clinical aspects. This enables readers from different fields-from the physician on the ward to the analytical chemist-to understand the whole process of therapeutic drug monitoring and to avoid common pitfalls which can arise in all steps of the process. The new edition contains updated information on analytical techniques for the quantification of drugs as well as pharmacogenetic and pharmacogenomic methods. Recent improvements in column technology for liquid chromatography are covered, as is the use of mass spectroscopy as a detector for all chargeable compounds, which is becoming affordable for many laboratories. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. Coverage has been expanded to drugs new to the market, such as tyrosine kinase inhibitors in oncology and the monitoring of immunosuppressant drugs. The chapter on pharmacokinetic methods is also now streamlined to focus on the applied statistical methods in order to clearly explain the procedures and possible pitfalls. Unique interdisciplinary approach appeals to a wide range of users, ensuring more successful drug monitoring applications in a number of clinical environmentsEach chapter is written by an author from an international lab, providing a global perspective that can be applied in various regulatory environmentsFeatures additional therapeutic drugs to reflect the rising number of immunocompromised patientsIncludes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories INDICE: 1. Sample Preparation for the Analysis of Drugs in Biological Fluids2. Chromatographic methods for the analysis of drugs in biological fluids3. Mass Spectrometry as a tool in therapeutic drug monitoring4. Capillary Electrophoresis for the determination of drugs in biological fluids5. Immunoassays for the determination of drugs in biological fluids6. Validation of bioanalytical methods7. Pharmacokinetic methods for the analysis, interpretation and management of TDM data for individualising drug dosage regimens optimally8. Dose and therapy individualisation in cancer chemotherapy9. Therapeutic drug monitoring of antibacterial therapy10. Therapeutic Drug Monitoring of Antifungals11. Therapeutic Drug Monitoring of Antiviral Drugs12. Therapeutic drug monitoring of antiepileptic drugs13. Therapeutic drug monitoring of antipsychotic and antidepressant drugs14. Monitoring imunosuppressant drugs15. Pharmacogenetic and pharmacogenomics methods for genotyping and phenotyping in the context of drug therapy 16. Applications of genotyping and phenotyping for clinical relevant polymorphisms of drug metabolising enzymes and drug transporters
- ISBN: 978-0-444-64066-6
- Editorial: Elsevier Science
- Encuadernacion: Rústica
- Páginas: 500
- Fecha Publicación: 01/09/2019
- Nº Volúmenes: 1
- Idioma: Inglés