Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside

Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches.  The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease. Covers the broad field of bone sarcomas and bone metastases from basic research to clinical approaches Presents comprehensive and translational overview of biological and clinical aspects of bone cancers, discussing pathophysiology from genetic and molecular levels using the most recent evidence Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays INDICE: Epidemiology of Bone Cancer 1. Osteoarchaeology: lessons to learn from the past 2. Epidemiology of primary bone tumors and economical aspects of bone metastases Models of Bone Cancers and Technical Aspects Animal Models 3. Animal models of bone sarcomas 4. In vivo models used in studies of bone metastaes 5. Zebrafish models for studying bone tumors Mathematic models and machine learning 6. Use of machine learning in bone cancers 7. Artifical intelligence for bone cancer imaging Preparation of tissue samples: technical aspects 8. Technical aspects: how do we best prepare bone samples for proper histological analysis? Bone Microenvironment and Bone Cancer Bone niche 9. Bone niche and bone metastases 10. Bone: a fertil soil for tumor development 11. Osteomimicry: old concepts and new findings Dialog between cancer cells and bone cells 12. Role of mesenchymal stem cells in bone cancers, initiation, propagation and metastasis 13. Technical approaches for studying the communications between osteocytes and cancer cells 14. Osteocytes and bone cancers 15. Immune functions of osteoclasts: new insights for bone cancers 16. Immune infiltrate in bone sarcomas 17. Macrophages and pathophysiology of bone cancers Mediators of cell communications 18. Growth factors, cytokines and pediatric malignant primary bones tumors 19. The role of NFkB in bone cancer 20. TGF-beta and bone cancers: a specific focus 21. Extracellular vesicles, tumor growth and metastatic process 22. Connexin43 and development of primary bone tumors : osteosarcoma and Ewing's sarcoma 23. The role of endocannabinoid system in bone cancer Metabolism 24. Impact of the microenvironment acidosis on bone cancers 25. Hypoxic niche and bone cancers 26. Metabolism and bone cancers Bone Tumor Heterogeneity, Plasticity and Biomarkers Heterogeneity and plasticity 27. EMT process in bone metastasis 28. Cancer stem cells and clonal evolution in bone sarcomas 29. Dormancy in cancer bone metastasis Biomarkers 30. Bone Remodelling Markers and Bone Cancer 31. Epigenetic Heterogeneity in Primary Bone Cancers 32. miRNA implication in therapeutic resistance and metastatic dissemination of bone-associated tumors 33. MicroRNAs and bone metastasis: how small RNAs regulate secondary tumour formation and progression in the skeleton 34. Long-non coding RNA and bone sarcoma 35. Liquid biopsy and circulating tumor cells in bone sarcomas: identification of new biomarkers and analysis of the tumor heterogeneity 36. Disseminated tumor cells in bone marrow of cancer patients II. PRIMARY BONE TUMORS Biological aspects 37. Cytogenetics of bone sarcomas 38. Genetic aspects of primary bone tumors 39. Markers of bone sarcomas 40. Molecular pathology of osteosarcoma 41. Genomic and proteomic profiling of osteosarcoma 42. Ewing sarcoma family of tumors 43. Molecular aspects of Ewing sarcomas 44. Osteoclast-rich lesions: a clinical and molecular overview 45. Biology of cartilage tumor family Clinical aspects and Perspectives Imaging 46. Imaging of bone sarcomas Therapeutic approaches 47. Current therapeutic approaches of bone sarcomas 48. Surgical approaches of bone sarcomas: Margins and clinical impact 49. Apoptosis and drug resistance in malignant bone tumors: impact on the clinical practices 50. Chondrosarcoma of Bone: Diagnosis and Therapy 51. Radiotherapy and Primary bone tumors 52. New therapeutic advances of bone sarcomas III. BONE METASTASES Biological aspects 53. The histopathology of skeletal Metastases 54. Indentification of new therapeutic targets of bone cancers by proteomic strategies Clinical aspects and Perspectives Imaging 55. Interventional radiologic techniques in management of bone tumors 56. Diagnosis of bone metastases in urological malignancies - an update Bone pain 57. Mechanisms and management of bone cancer pain 58. Involvement of sympathic nerves in bone mestastasis 59. Pain control with palliative radiotherapy in patients with bone metastases 60. Palliative care of bone metastases Therapeutic approaches 61. Radiotherapy of bone metastases 62. Cellular and molecular actions of bisphosphonates: therapeutic interest in tumor-associated bone diseases 63. Bone-Targeted agents and skeletal-related events in breast cancer patients with bone metastases 64. Bone metastases - current status of bone-targeted treatments 65. Therapies of bone metastases in castration-resistant prostate cancer 66. Therapy with bone-targeting radiopharmaceuticals 67. Therapeutic approaches of bone metastases associated with breast cancer MYELOMA: A BONE ASSOCIATED DISEASE 68. Biological relationship between bone and myeloma cells 69. Recent therapeutic approaches in myeloma

• ISBN: 978-0-12-821666-8
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 1078
• Fecha Publicación: 22/09/2021
• Nº Volúmenes: 1
• Idioma: Inglés