Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation ofhuman cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in ‘cancer stem cells’ has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge. Will focus on telomere and telomerase in human cancers and may provide medical doctors, pathologists, and translational cancer researchers with a deep understanding of these unique and fascinating molecules, as well as hot topics in clinical applications INDICE: From the contents Part I. Basic background. 1 Telomeres and Telomerase in Human. 2 Telomere Binding Proteins in Human. 3 Regulation of Telomerase through Transcriptional and Post-Translational Mechanisms. 4 Telomere Dysfunction and the DNA Damage Response. 5 Alternative Lengthening of Telomeres (ALT) in Human Cells. 6 Mouse model: Telomeres and Telomerase in Stem Cell and Cancer.- Part II Telomeres and telomerase in human cancers. 7 Role of Telomeres and Telomerase in Cancer. 8 Diagnostic Value 1: Solid Tumors. 9 Diagnostic Value 2: Hematopoietic Malignancies. 10 Therapeutic Targets and Drugs 1: Telomerase and Telomerase Inhibitors. 11 Therapeutic Targets and Drugs 2: G-quadruplex and G-quadruplex Inhibitors. 12 Therapeutic Targets and Drugs 3: Tankyrase 1, Telomere Binding Proteins, and Inhibitors. 13 Therapeutic Targets and Drugs 4:Telomerase-specific Gene and Vector-based Therapies for Human Cancer.
- ISBN: 978-1-60327-306-0
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 315
- Fecha Publicación: 01/02/2009
- Nº Volúmenes: 1
- Idioma: Inglés