Organ on a Chip: Convergence of Advanced Materials, Cells, and Microscale Technologies

Organ on a Chip: Convergence of Advanced Materials, Cells, and Microscale Technologies contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models. Includes case studies of other organs on a chip that have been developed and successfully usedProvides insights into functional microphysiological organ on a chip platforms for toxicity and efficacy testing, along with opportunities for translational medicinePresented fields (PK/PD, physiology, medicine, safety) are given a definition followed by the challenges and potential of organs on a chip INDICE: 1. Need for alternative methods 2. Cell sources for creating different organ systems 3. Organs-on-a-chip (introduction) PART I Ooc platforms to model disease pathogenesis 4. Lung 5. Liver 6. Brain 7. Kidney 8. Heart 9. C.Elegans-on-a-chip 10. Intestine 11. Ooc Platform to model safety toxicology and drug 12. OoC Platforms for translational Medicine applications 13. OoC microdevices to model key pharmacokinetic processes PART II Multi-organs-on-a-chip Platforms to mimic Humans Physiology 14. Multi-organs-on-a-chip 15. Human-on-a-chip 16. Automation and opportunities for Industry Scale-up of OoC Platforms 17. How to develop your chip - A case study

• ISBN: 978-0-12-817202-5
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 400
• Fecha Publicación: 01/12/2019
• Nº Volúmenes: 1
• Idioma: Inglés