Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapiesHelps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspringChapters are replete with clinical examples to empower the basic biology with translational significanceOffers more than 100 illustrations to distill key concepts and decipher complex science INDICE: Preface1. Introduction and History2. Histone modifications3. Genomic Imprinting4. Polycomb/trithorax group factors in cancer in gene regulation5. Chromatin dynamics and genome organization6. ncRNA function in chromatin organization7. Epigenetic Gene Regulation and stem cell function 8. Epigenetic Regulation of Cell Growth and Senescence9. Epigenetic Inheritances 10. Transgenerational epigenetic changes 11. Current methods for epigenetic analysis12. Cell Cycle and Cell Differentiation13. Developmental Gene Regulation and tissue development14. Epigenetic regulation and Cancer15. ncRNA and carcinogenesis16. Epigenetic gene regulation during Aging17. Role of epigenetic mechanisms in environmental/toxicology/nutritional Gene regulation18. Evolutionary implications of Epigenetic gene regulation19. Epigenetic Biomarkers 20. Epigenetic drugs and therapy21. Clinical Implications and Case Studies

• ISBN: 978-0-12-799958-6
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 400
• Fecha Publicación: 01/08/2015
• Nº Volúmenes: 1
• Idioma: Inglés