Amino acids, peptides and proteins in organic chemistry v. 3 Building blocks, catalysis and coupling chemistry

Closing a gap in the literature, this is the only book series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, this series is a real benchmark for amino acid chemistry, providing a comprehensive discussion ofthe occurrence, uses and applications of amino acids and, by extension, theirpolymeric forms, peptides and proteins. The practical value of each volume isheightened by the inclusion of experimental procedures. This third volume in the series presents an in depth account of recent developments in the (bio-)synthesis of amino acids and peptides. Divided into two parts, the first sectiondeals with amino acids as building blocks, including the generation of alpha-amino acids, beta-lactams, and heterocycles. The second section is devoted to the synthesis of peptides, with the focus on solid phase synthesis. However, solution phase peptide synthesis is covered as well, as are topics such as coupling reagents, chemical ligation, peptide purification and automation INDICE: AMINO ACIDS AS BUILDING BLOCKS Alpha-Amino Acid Biosnythesis (Proteinogenic and Non-Proteinogenic) Heterocycles from Amino Acids Radical Synthetic Methods for Alpha-Amino Acids Enzymatic or Microbial Beta-Lactam Synthesis AMINO ACID COUPLING CHEMISTRY Solution Phase Peptide Synthesis Solid Phase Peptide Synthesis: Historical Aspects Solid Phase Peptide Synthesis: Linkers Solid Phase Peptide Synthesis: The Fmoc Methodology 1 Solid Phase Peptide Synthesis: The Fmoc Methodology 2 Solid Phase Peptide Synthesis: SPPS Strategies Coupling Reagents Chemical Ligation Automation of Peptide Synthesis Peptide Purification Difficult Peptides

• ISBN: 978-3-527-32102-5
• Editorial: Wiley-VCH
• Encuadernacion: Cartoné
• Páginas: 624
• Fecha Publicación: 15/12/2010
• Nº Volúmenes: 1
• Idioma: Inglés