Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment. Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research. Offers a thorough foundation in epigenetics and DNA damage research, as well as informed discussion of evolving research trends, disease findings, and early therapeutics Features chapter contributions from leading international contributors Empowers scientists to apply protocols in DNA damage and epigenetic alteration analysis and experimatation in their own research INDICE: 1. Introduction Miriam Galvonas Jasiulionis2. DNA damage and DNA methylation3. DNA damage and histone modifications4. DNA damage and histone variants5. DNA damage and chromatin regulators6. DNA damage and miRNAs7. DNA damage and lncRNAs8. DNA damage, SIRT1 and epigenetic marks9. DNA damage, metabolic alterations and epigenetic changes10. DNA damage, diet and epigenetic changes11. DNA damage, epigenetics and aging12. DNA damage, epigenetics and pluripotent stem cell differentiation13. DNA damage, epigenetics and chronic inflammatory diseases14. DNA damage, epigenetic alterations and immune dysfunction15. DNA repair, epigenetics and trinucleotide repeat ataxias16. DNA damage, epigenetics and cancer17. Oncometabolites, epigenetic marks and DNA repair18. Therapies inducing DNA damage19. Epigenetic therapy20. Therapeutic strategies combining damage induction and epigenetic alterations21. Useful protocols to study DNA damage22. Useful protocols to study epigenetic modifications23. Interplay between DNA repair and epigenetics: Future directions
- ISBN: 978-0-323-91081-1
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 408
- Fecha Publicación: 15/08/2022
- Nº Volúmenes: 1
- Idioma: Inglés