Nanomedicine in CNS Injury and Repair (IRN)

Nanomedicine in CNS Injury and Repair (IRN), Volume 136, the latest release in the International Review of Neurobiology series presents comprehensive chapters that cover a broad range of topics, including, but not limited to, how Diabetes exacerbates methamphetamine induced blood-brain barrier breakdown, edema formation, oxidative stress and myelin damage, and how Focal blast brain injury induces rapid edema formation, blood-brain barrier breakdown and intensive cellular damage. In addition, the Neuroprotective effects of a multimodal drug cerebrolysin are explored, as is how Nanowired cerebrolysin potentiates neuroprotective effects of histamine H3 receptor inverse agonist and antagonist with partial H4 agonist in Alzheimer's Disease. This series reviews current knowledge and understanding on how to repair the damaged spinal cord and brain with nanomedicine, detailing new therapeutic advances and providing a starting point for researchers and practitioners entering the field. Provides cutting-edge research on the damaged spinal cord and brainPresents new therapeutic advancesReviews current knowledge and understanding INDICE: 1. Diabetes exacerbates methamphetamine induced blood-brain barrier breakdown, edema formation, oxidative stress and myelin damage. Neuroprotective effects of nanowired delivery of antioxidant compound H-290/512. Focal blast brain injury induces rapid edema formation, blood-brain barrier breakdown and intensive cellular damage. Neuroprotective effects of a multimodal drug cerebrolysin3. Nanowired cerebrolysin potentiates neuroprotective effects of histamine H3 receptor inverse agonist and antagonist with partial H4 agonist in Alzheimer's Disease4. Repeated topical application of Acure compound AP-173 enhances neuroprotective efficacy and early functional recovery following spinal cord trauma. A comparative study using systemic dexamethasone treatment in the rat5. Sleep deprivation aggravates brain pathology in Alzheimer's disease. Enhanced neuroprotection with co-administration of nanowired 5-HT6 receptor antagonist SB-399885 and cerebrolysin6. Co-administration of nanowired mesenchymal stem cells with antioxidant H-290/51 ameliorates exacerbation of spinal cord pathology following trauma in hypertensive rats7. Concussive head injury at simulated high altitude exacerbates blood-brain barrier breakdown, edema formation and cellular injury. Neuroprotection by nanowired delivery of cerebrolysin with mesenchymal stem cells8. Concussive head injury induced brain ischemia and oxidative stress are thwarted by nanodelivery of Chinese traditional medicine DL-3-n-butylphthalide (DL-NBP)9. Gold Nanoparticles (AuNPs 40 nm) aggravate whole body hyperthermia induced blood-brain barrier breakdown, edema formation and cellular injuries. Neuroprotective effects of nanowired cerebrolysin10. PLGA nanoparticles loaded cerebrolysin attenuates CSF and brain levels of F-2 isoprostane and p-tau in Alzheimer's disease11. Nanodelivery of cerebrolysin reduces alpha-synuclein, neuronal nitric oxide synthase and brain pathology in Parkinson's disease12. Nanoparticles exacerbate Nicotine induced brain pathology following closed head injury

• ISBN: 978-0-12-812381-2
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 322
• Fecha Publicación: 15/11/2017
• Nº Volúmenes: 1
• Idioma: Inglés