Lantibiotics as Alternative Therapeutics

Lantibiotics as Alternative Therapeutics explores alternative therapeutics, lantibiotics and other novel drugs. This book provides concrete information to readers regarding lantibiotics and various types of antimicrobial peptides with their mode of actions in treating various multidrug resistant organisms. It explains various techniques that are involved in analyzing antimicrobial peptides and their mode of actions. The development of antibiotic resistance has now reached a point of crisis where innovative methods and application of novel compounds and methods are required to prevent the spread of drug resistant infections. Novel compounds exhibit different modes of action to the currently used mechanism of therapeutics in order to combat against the resistant organisms. Lantibiotics hold considerable potential as a consequence of their unusual structure, unique mechanisms of action and their potency against multi-drug resistant bacteria. This book will be useful for pharmaceutical industry scientists and researchers in microbial and biomedical research as well as graduate and advanced students in microbiology, medical biotechnology, health, and pharmaceutical sciences. Includes the biology, molecular interaction with target molecule, putative genes and analytical techniques to isolate and identify compounds Incorporates relevant case studies to increase understanding Focuses on recent trends on novel antimicrobial agents and antibiotic resistance research Discusses new arena of diseases, apart from acute and chronic infections INDICE: 1. Genetics of the development of antibiotic and multi-drug resistance2. Antimicrobial peptides and the potent mechanism of action3. Lantibiotics and Gene regulation 4. Biosynthesis of Lantibiotics5. Optimizations in the productions of Lantibiotics and Scale-Up6. Analytical Techniques in Identifying & Purifying the proteins7. Development of Recombinant Lantibiotics and their Potent Uses8. Mechanism of Action of the Lantibiotics on the Multi-Drug Resistant Organism9. Mechanism of inhibiting Biofilm associated Chronic Infections by Lantibiotics10. Lantibiotics & Its Role in Food Preservation11. In-Silico studies of the Interaction of Lantibiotics with Virulent Proteins12. Insights at the atomistic resolution of Lantibiotics using Multiscale Simulations13. Case studies: Applications of such novel drugs14. Recent updates in understanding of molecular genetics of lantibiotics production15. In silico molecular modelling approach for better designing and applications16. Marine microbes as a potential source of novel drugs17. Combinations of nano-bio molecules as next generation antimicrobial agents

• ISBN: 978-0-323-99141-4
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 350
• Fecha Publicación: 01/03/2023
• Nº Volúmenes: 1
• Idioma: Inglés