This book comprehensively describes the development and practice of DNA–encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that differs from more classical approaches like high throughput screening, offering attractive alternatives to resource– and cost–intensive corporate chemical libraries for screening and lead discovery. The book: Provides a valuable guide for understanding and applying DNA–encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA–encoded combinatorial chemistry – chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery Provides expert and up–to–date summary of reported literature for DNA–encoded and DNA–directed chemistry technology and methods INDICE: Acknowledgements Preface Introductory comments Foreword 1 Just enough knowledge 2 A brief history of the development of combinatorial chemistry and the emerging need for DNA–encoded chemistry 3 A history of DNA–encoding 4 DNA–Compatible Chemistry 5 Foundations of a DNA–encoded library (DEL) 6 Practices for synthesizing DNA–encoded libraries 7 Chemical gene design for DNA–encoded libraries 8 Analytical challenges for DNA–encoded library systems 9 Information technology: Functionality and architectures for DNA–encoding 10 Theoretical considerations of the application of DNA–encoded libraries to drug discovery 11 Begin with the End in Mind: The hit–to–lead process 12 Enumeration and Visualization of Large Combinatorial Chemical Libraries 13 Screening Large Compound Collections 14 Reported applications of DNA–encoded library chemistry 15 Dual–Pharmacophore DNA–Encoded Chemical Libraries 16 Hit Identification and Hit Follow–up 17 Using DNA to Program Chemical Synthesis, Discover New Reactions, and Detect Ligand Binding 18 An Outlook and the changing feasibility and economics of chemical diversity exploration with DNA–encoded combinatorial approaches 19 Keeping the promise? An outlook on DNA chemical library technology Index
- ISBN: 978-1-118-48768-6
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 484
- Fecha Publicación: 20/06/2014
- Nº Volúmenes: 1
- Idioma: Inglés