Bone Remodelling Process: From Biology to Mechanobiological Modelling

Bone remodelling process provides a literature review; first, of bone in a normal physiological condition, bringing together the involved actors and factors reported over the past two decades, and second, in pathological conditions, highlighting the attack vectors of each bone disease. The third part of this book is devoted to the mathematical descriptions of bone remodelling, formulated to develop models able to provide information that is not amenable to direct measurement, while the last part focuses on models using the finite element method in investigating bone biomechanics. The book builds an overall image of the complex communication network established between the diverse remodelling actors, based on overwhelming control evidence revealed over recent years, as well visualizes the remodelling defects and possible treatments in each case. It also regroups the models allowing readers to analyse and asses bone mechanical and biological properties. This book details the cellular mechanisms allowing bone to adapt its microarchitecture to the requirements of the human body, which is a main issue in bone biology and presents the evolution of mathematical modelling used in bone computer simulation. Each chapter covers a core topic in bone biomechanicsProvides a multidisciplinary view that effectively links orthopaedics, cellular biology, mechanics, and computer simulationDraws an overall image about bone biology and cell interactions, for identifying cell populations that are crucial for the remodelling process INDICE: 1. Bone remodelling biology2. Bone diseases and therapeutic solutions3. Remodelling In vitro4. Bone remodelling mathematical models5. Finite element modelling of bone remodelling

• ISBN: 978-0-323-88467-9
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 200
• Fecha Publicación: 01/07/2021
• Nº Volúmenes: 1
• Idioma: Inglés