Chemical Analysis of Non-antimicrobial Veterinary Drug Residues in Food

Provides a single–source reference for readers interested in the development of analytical methods for analyzing non–antimicrobial veterinary drug residues in food Provides a comprehensive set of information in the area of consumer food safety and international trade Covers general issues related to analytical quality control and quality assurance, measurement uncertainty, screening and confirmatory methods Details many techniques including nanotechnology and aptamer based assays covering current and potential applications for non–antimicrobial veterinary drugs Provides guidance for analysis of banned drugs including natural and synthetic steroids, Resorcylic acid lactones, and Beta–agonists INDICE: Preface .List of contributors .About the Editors .Chapter 1: Basic Considerations for the Analyst for Veterinary Drug Residues Analysis in Animal Tissues James D. MacNeil and Jack F. Kay .1.1 Introduction .1.2 Pharmacokinetics .1.3 Metabolism and Distribution .1.4 Choice of Analytical Method .1.5 Importance of Regulatory Limits .1.6 International Obligations for Regulatory Analytical Laboratories .1.7 Conclusions .References .Chapter 2: Emerging Techniques in Sample Extraction and Rapid Analysis Wendy C. Andersen, Sherri B. Turnipseed, and Jack J. Lohne .2.1 Introduction .2.2. Sample Extraction .2.3. Extract Clean–Up with Solid Phase Sorbents .2.4. Micro Extraction Techniques for Solvent and Sorbent Extraction .2.5 Emerging Techniques in Liquid Chromatography .2.6 Direct Mass Spectrometry Analysis of Sample Extracts .2.7 Ion Mobility Spectrometry .2.8 Conclusions .References .Chapter 3: Capabilities and Limitations of High Resolution Mass Spectrometry (HRMS): Time of Flight and Orbitrap Anton Kaufmann and Phil Teale .3.1 Available Technology .3.2 Capabilities and Limitations of the Technology as Compared to LC–MS/MS (Tandem Quadrupole Mass Spectrometer) .3.3 Analytical Methods for Veterinary Drug Residues .3.4 Doping Control .3.5 Accurate Mass MS in Research and Metabolism Studies .3.6 Designer Drugs and Generic Detection Strategies .3.7 The Future of Accurate Mass Spectrometry in Residue Analysis .Chapter 4: Hormones and –Agonists Leendert A. van Ginkel, Toine Bovee, Marco H. Blokland, Saskia S, Sterk, Nathalie G.E. Smits, Jelka Pleadin and Ana Vuli .4.1 Introduction .4.2 Advances in Classical Analysis of Exogenous Synthetic Hormones .4.3 Bio–based Screening Methods for Steroid Hormones, –Agonists and Growth Hormones .4.4 Natural Hormones .4.5 Control for Synthetic –agonists: Screening and Confirmatory Methods .References .Chapter 5: Analysis of Anthelmintic and Anticoccidial Drug Residues in Animal–Derived Foods Sarah Tuck, Ambrose Furey and Martin Danaher .5.1 Introduction .5.2 Chemistry and Mode of Action .5.3 Legislation .5.4 Sample Preparation Protocols for Antiparasitic Agents in Food Matrices .5.5 LC–MS and GC–MS Detection of Antiparasitic Agents in Food .5.6 Conclusions .References .Chapter 6: Sedatives and Tranquilizers Vesna Cerkvenik Flajs and James D. MacNeil .6.1 Introduction .6.2 Classification and Representative Compounds .6.3 Use of Sedatives and Tranquilizers to Prevent Stress Syndrome During the Transport of Pigs to Slaughter .6.4 Sedatives and Tranquilizers with an Approved Veterinary Use in Food–producing Animals .6.5 Sedatives and Tranquilizers without an Approved Veterinary Use in Food–producing Animals .6.6 Cocktails .6.7 Issues of Environmental Contamination .6.8 Maximum Residue Limits (MRLs) .6.9 Systematic Veterinary Control over Residues and Surveillance Studies .6.10 Analyte Stability .6.11 Analytical Methods for Determination of Residues .6.12 Performance and Validation of the Analytical Methods .References .Chapter 7: The Use of Pyrethroids, Carbamates, Organophosphates and Other Pesticides in Veterinary Medicine Christine Akre .7.1 Introduction .7.2 Veterinary Drug Properties, Structures and Regulation .7.3 Toxicology, Pharmacokinetics and Metabolism .7.4 Analytical Methods .7.5 Conclusion .References .Chapter 8: Non–steroidal Anti–inflammatory Drugs Joe O. Boison, Fernando J. Ramos and Alan Chicoine .8.1. Introduction: What are Pain Killers (Analgesics) and NSAIDs? .8.2. Veterinary Drug Properties, Structures, and Regulation .8.3. Pharmacokinetics/Metabolism .8.4 Acceptable Daily Intake (ADI) .8.5. Maximum Residue Limits/Tolerances .8.6. Analysis of NSAID Residues in Food .8.7. Literature Reviews of Analytical Methods for NSAIDs in Biological Samples .8.8 New Developments in NSAIDs .8.9. Conclusion .References .Chapter 9: Certain Dyes as Pharmacologically Active Substances in Fish Farming and other Aquaculture Products Eric Verdon and Wendy C. Andersen .9.1 Introduction .9.2 Therapeutic Applications and Chemistry of Certain Dyes used in Fish .Farming .9.3 Toxicological Issues .9.4 Regulatory Issues .9.5 Analytical Methods for Residue Control .9.6. Recent Trading Issues with Dye Alerts .9.7 Conclusions .References .Chapter 10: Method Validation and QA/QC Approaches for Multi–residue Methods Andrew Cannavan, Jack F. Kay and Zora Jandri .10.1 Introduction .10.2 Sources of Guidance on Method Validation .10.3 Practical Considerations .10.4 Examples of Validation Protocols for MRMs .10.5 Quality Assurance / Quality Control .10.6 Conclusion .References .INDEX

• ISBN: 978-1-118-69507-4
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 640
• Fecha Publicación: 02/12/2016
• Nº Volúmenes: 1
• Idioma: Inglés