Translational Glycobiology in Human Health and Disease

Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment. Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences. Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery. Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology's growing role in human health and disease studyExamines a broad range of relevant disease areas and applications of glycobiology in policy and public healthFeatures chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciencess INDICE: 1. Introduction Section 1: Glycobiology 2. Carbohydrates and human glycosylation 3. Carbohydrate-binding proteins 4. Carbohydrate-active enzymes Section 2: Glycobiology and health 5. Glycoimmunology 6. Neuroglycobiology 7. Commensal glycobiology and gut health 8. Microbiota accessible carbohydrates and the gut microbiome 9. Regenerative medicine and glycobiology 10. Exosome glycosylation for signalling and function Section 3: Glycobiology and disease 11. Cancer  12. Altered glycosylation in autoimmune diseases 13. Metabolic diseases: Disorders of carbohydrate metabolism and lysosomal storage 14. Congenital Disorders of Glycosylation 15. Microbial infectious disease glycobiology 16. Parasite glycobiology 17. Glycobiology of neurodegenerative diseases  18. Glycobiology of neural injury and regeneration Section 4: Glycotechnologies 19. Diagnostics and novel carbohydrate recognition molecules 20. Advanced glycoanalytics 21. Glycomics microarrays 22. Glycoengineering and systems biology 23. Computational Glycobiology 24. Carbohydrate-incorporated Biomaterials Section 5: Glycobiology and Society 25. Translational glycobiology and entrepreneurship for health 26. Glycobiology: Public engagement and society 27. Policy and regulatory requirements for glycosylation  28. Public health and translational glycobiology 29. Future perspectives/ summary

• ISBN: 978-0-12-819655-7
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 480
• Fecha Publicación: 01/09/2020
• Nº Volúmenes: 1
• Idioma: Inglés