Dyneins: Structure, Biology and Disease, Second Editionoffers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development. To account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 to 42 chapters, and is now housed in two volumes. Much of the expanded coverage occurs in Volume 2 which focuses on dynein dysfunction and disease, such as the role of dynein and cancer. Volume 1 covers the history and evolution of dyneins, dyneins in ciliary biology, and cytoplasmic dynein biology, while Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease. Presents a broad-based and up-to date view of dynein mechanics, dysfunction, and diseaseContains approaches from genetics, molecular biology, biochemistry, and biophysics discussedProvides companion website with movies of dynamic cell behaviorIncludes extensive chapters written by leading, global experts INDICE: I. Structure and Mechanics of Dynein Motors 1. Electron microscopy of isolated dynein complexes and the dynein power stroke mechanism 2. High resolution structures of dynein motor and microtubule-binding domains 3. Structural analysis of dynein intermediate and light chains 4. Biochemical purification of native and recombinant dyneins 5. Single molecule dynein motor mechanics in vitro 6. Biophysical properties of dynein in vivo 7. Inhibitors of dynein motors II. Dynein Dysfunction and Disease 1. Role of dynein in viral pathogenesis 2. Cytoplasmic dynein defects in a mouse model of distal spinal muscular atrophy 3. Lissencephaly, cortical malformations and the abnormal regulation of cytoplasmic dynein 4. Cytoplasmic dynein dysfunction and neurodegenerative disorders 5. Lis1-mediated regulation of hematopoietic stem cell fate and leukemia 6. The role of dynein in cancer 7. Dynein light chain mutations and congenital mirror movement disorder 8. Dynein dysfunction as a cause of primary ciliary dyskinesia 9. Severe skeletal abnormalities caused by defects in retrograde intraflagellar transport 10. Dynein dysfunction as a cause of situs inversus, heterotaxy and congenital heart disease 11. Dynein-based motility in parasite pathogenesis 12. Does dynein influence the non-Mendelian inheritance of chromosome 17 homologs in male mice?
- ISBN: 978-0-12-809470-9
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 514
- Fecha Publicación: 01/11/2017
- Nº Volúmenes: 1
- Idioma: Inglés