Dyneins 2/e Volume 1: Biology of Dynein Motors offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. Together with the separate, related volume 2 Dynein Mechanics, Dysfunction and Disease, these works provide an overview of dyneins from structure and function to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. To account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 chapters to 42 chapters and is now housed in two volumes. Much of the expanded coverage occurs in volume 2 on dynein dysfunction and disease such as the role of dynein and cancer. Volume 1 covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology. Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease. Broad-based up-to date view of the biology of dynein motorsApproaches from genetics, molecular biology, biochemistry, and biophysics discussedCompanion website with movies of dynamic cell behaviorChapters written by world experts INDICE: I.History and Evolution 1. Discovery of dynein and its properties: a personal account 2. Evolutionary biology of dyneins 3. Diversity of dynein-based systems and motile behavior across phylogeny II. Dyneins in Ciliary Biology 4. Cytoplasmic preassembly of axonemal dyneins and their trafficking to the cilium 5. Composition and assembly of axonemal dyneins 6. Organization of dyneins in the axoneme 7. Genetic approaches to axonemal dynein analysis 8. Regulation of axonemal outer and inner arm dyneins 9. Flagellar motility and the dynein regulatory complex 10. Regulation of dynein in ciliary and flagellar movement 11. Computational modeling of dynein activity and the generation of ciliary/flagellar waveforms 12. Dynein-mediated retrograde intraflagellar III. Cytoplasmic Dynein Biology 13. Cytoplasmic dynein function defined by subunit composition 14. Mechanisms of cytoplasmic dynein regulation 15. Insights into cytoplasmic dynein function from fungal genetics 16. Role of dynactin in dynein-mediated motility 17. Mechanisms of dynein-cargo interactions 18. Role of cytoplasmic dynein in mitotic checkpoint silencing 19. Role of cytoplasmic dynein in mitotic spindle assembly and activity 20. Dynein function during meiosis and oocyte maturation 21. Dynein activity in neurons 22. How does dynein track the microtubule +TIP? 23. Dynein-driven mRNA transport
- ISBN: 978-0-12-809471-6
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 618
- Fecha Publicación: 01/11/2017
- Nº Volúmenes: 1
- Idioma: Inglés