Unique work on structure-based drug design, covering multiple aspects of drugdiscovery and development. Fully colored, many images, computer animations of3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology indrug design, omics-technologies computational methods experimental techniquesof structure determination multiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting protein-protein interfaces. Unique reference work on the subject of drug design. Full colours throughout. Intelligibly written and illustrated containing over 100 computer graphics. Including an index of about 5,000 items. INDICE: 28. Agonists and antagonistsof nuclear receptors. 29. Agonists andantagonists of membrane-bound. 30. Ligands forchannels, pores and transporters. 31. Ligands for surfacereceptors. 32. Biologicals: Peptides, proteins, nucleotidesand macrolides as drugs.
- ISBN: 978-3-642-17906-8
- Editorial: Springer Berlin Heidelberg
- Encuadernacion: Cartoné
- Páginas: 720
- Fecha Publicación: 01/11/2011
- Nº Volúmenes: 1
- Idioma: Inglés