The increase in human contact with the toxic trace element thallium is associated with the development of industry, the release of this metal into the environment from various rocks and the use of special isotope techniques for studying the vascular bed. Mitochondria as a Key Intracellular Target of Thallium Toxicity lists the pathways and mechanisms of thallium transport into cells and mitochondria. This toxicity has been analyzed at both the cellular and subcellular levels. Mitochondria as a Key Intracellular Target of Thallium Toxicity presents a new hypothesis explaining the decrease in the antioxidant defense in the case of thallium poisoning and proposes a new model for studying the transport of inorganic cations across the inner mitochondrial membrane. Readers can expect to learn about the toxicity of thallium and its compounds, the toxicology of thallium, the toxic thallium effects on cells, and the effects of thallium on mitochondria. Highlights differences between the toxic effect of thallium and the action of other heavy metals on cells and mitochondria Explains why the toxicity of thallium in experiments in vivo is higher than that of bivalent heavy metals Discusses the applied in vitro model when searching for new inhibitors of the mitochondrial permeability transition pore INDICE: 1. Toxicity of thallium and its compounds 2. Toxicology of thallium 3. Toxic thallium effects on cells 4. Effects of thallium on mitochondria
- ISBN: 978-0-323-95531-7
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 200
- Fecha Publicación: 01/08/2022
- Nº Volúmenes: 1
- Idioma: Inglés