Smart Therapeutics: Synergistic Combinations presents the state-of-the-art on smart therapeutics, helping researchers develop new approaches for less toxic and more effective drug combinations. The book demonstrates that highly-toxic synthetic drugs may be rendered safe through synergistic combinations with natural products. The volume consists in six parts, giving a historical overview and covering drug development, drug interactions, synergic relations in drug discovery and combination therapy, calculations in designing synergistic combinations, and clinical approaches to synergistic combinations. This volume presents the latest work in combining natural and synthetic drugs for more effective, less toxic pharmaceuticals of use in clinical practice. Historically, the use of natural medicine was followed by the discovery of synthetic drugs, and in recent years, a resurgence in the use of natural substances which may have fewer negative side-effects when compared with synthetic drugs. Presents the history, development, design and clinical uses of combined natural and synthetic drugs Details new drug combinations that are less toxic, but at the same time more active than natural or synthetic drugs alone Presents interaction mechanisms, including both synergistic and antagonistic interactions Informs on new pharmaceutical and drug development studies in the use of natural and synthetic products Considers clinical approaches to synergistic combinations INDICE: Part 1. Introduction to the Historical overview for synergy in therapyPart 2. Drug development1. Drug development strategies and future view2. From Teriac to Aspirin3. Mixing and compounding in drug discovery.4. Combination therapy in pharmaceutical sciencesPart 3. Drug interactions1. From Pharmacology to toxicology2. Interactions in phytomedicines3. Natural product-natural product interactions4. Natural product-synthetic drug interactions5. Natural product-food/beverage interactions6. Interactions on genomic level: Pharmacognenomics aspectsPart 4. Synergic relations in drug discovery and combination therapy1. Synergy in nature and natural products2. Synergic essential oil combinations3. Synthetic drug+ natural product combinations4. Combination technologies5. The art of combination: pharmaceutical technology6. Combinatorial vs Combinational ChemistryPart 5. Calculations in designing of synergistic combinationsPart 6. Clinical approaches for synergistic combinations
- ISBN: 978-0-323-85478-8
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 330
- Fecha Publicación: 01/09/2022
- Nº Volúmenes: 1
- Idioma: Inglés