Insulin: Deficiency, Excess and Resistance in Human Disease provides an overview of the role of insulin in the pathogenesis of prevalent non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, and cancer, along with a comprehensive review of insulin replacement therapies and novel cardioprotective and insulin-sensitizing drugs. Notable advances in precision diagnosis and therapy for single gene subtypes of diabetes in recent years are also discussed. The discovery of insulin and its lifesaving introduction into clinical practice is one of the most celebrated accomplishments of medical science. However, despite decades of progress and major technical advances, the goal of providing insulin replacement therapy that truly mimics normal physiology remains elusive. Presents etiology and pathogenesis of insulin deficiency, insulin excess and insulin resistance in a wide spectrum of human diseases, ranging from rare to highly prevalent disorders Discusses the latest developments in the diagnosis and management of insulin-related disorders and prospects for future developments Explores the increasingly complex pharmacological landscape that comprises a bewildering range of drug-based interventions INDICE: Part 1. Normal physiology 1. Insulin synthesis and secretion 2. Metabolic regulation by insulin3. Non-classic effects of insulin Part 2. Disorders of Insulin Deficiency 4. Type 1 diabetes 5. Exogenous insulin replacement in type 1 diabetes6. Pancreas and Islet transplantation7. Treatment: artificial pancreas, immune modulation, stem cell therapy 8. Research methods in type 1 diabetes9. Secondary forms of diabetes (type 4 diabetes)Part 3. Syndromes of Insulin Excess10. Congenital hyperinsulinism11. Insulinoma and nesidioblastosis12. Other causes of insulin excessPart 4. Insulin Resistance in Human Disease13. Etiopathogenesis of insulin resistance14. Obesity and insulin resistance15. Type 2 diabetes16. The cardiometabolic syndrome17. Insulin and cancer18. Insulin and neurodegenerative diseases19. Obesity management - nonpharmacological and pharmacological 20. Remission of type 2 diabetes via medical nutrition therapy21. Bariatric surgery for obesity and related disorders22. Pharmacotherapy for type 2 diabetes and associated cardiometabolic risk23. Syndromes of severe insulin resistance24. Research methods in obesity and type 2 diabetes25. Future prospects for disorders of defective insulin physiology
- ISBN: 978-0-323-91707-0
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 300
- Fecha Publicación: 01/10/2022
- Nº Volúmenes: 1
- Idioma: Inglés