Oncogenes meet metabolism: from deregulated genes to a broader understanding of tumour physiology

In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour researchhas shifted towards the search for oncogenes. However, the interest in cancermolecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help ofmodern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics). INDICE: Mitochondria and Cancer.- Role of Metabolic Stress Responses of Apoptosis and Autophagy in Tumor Suppression.- The Interplay Between MYC and HIFin the Warburg Effect.- Using Metabolomics to Monitor Anticancer Drugs.- Biomarker Discovery for Drug Development and Translational Medicine Using Metabonomics.- Pyruvate Kinase Type M2: A Key Regulator Within the Tumour Metabolome and a Tool for Metabolic Profiling of Tumours.- Molecular Imaging of Tumor Metabolism and Apoptosis.-Minimally Invasive Biomarkers for Therapy Monitoring.- Use of Metabolic Pathway Flux Information in Anti-Cancer Drug Design.- Cancer Diagnostics Using H-NMR-Based Metabonomics.- Exploiting the Potential of Metabonomics in Large Population Studies.- Defining Personal Nutrition and MetabolicHealth Through Metabonomics.

• ISBN: 978-3-540-79477-6
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 255
• Fecha Publicación: 01/09/2008
• Nº Volúmenes: 1
• Idioma: Inglés