Clinical Molecular Medicine uniquely presents the latest scientific advances in molecular and cellular biology within a clinical context. The field of clinical molecular medicine is vital to the development of new and effective drug and biological therapies and diagnostic methods. The objective of this book is to provide medical and biomedical students and researchers with a clear and clinically relevant understanding of the molecular basis of human disease based on the latest scientific evidence. With an increased focus on new practice concepts such as stratified, personalized and precision medicine, this book is a valuable and much-needed resource that unites the core principles of molecular biology with the latest and most promising genomic advances in order to further the field and promise of clinical molecular therapeutics. Illustrates the fundamental principles and therapeutic applications of molecular and cellular biologyOffers a clinically focused account of molecular heterogeneityIncludes comprehensive coverage of many different disorders, including growth and development, cardiovascular, metabolic, skin, blood, digestive, inflammatory, neuropsychiatric disorders and many more INDICE: Section I Fundamentals of Molecular and Cell Biology 1. Genes, genome and chromosomes 2. Cellular structure and molecular systems 3. RNA, Transcription factors and Ribosome 4. Proteins and Proteomics 5. Mitochondria and oxidative phosphorylation 6. Reproductive and developmental molecular biology 7. Genomic variation, molecular basis of evolution, comparative molecular biology 8. Bioinformatics and systems biology Section II Molecular basis of human disease 9. Molecular basis of growth disorders: Primordial growth disorders; Overgrowth and asymmetric growth disorders 10. Developmental disorders: major molecular groups and malformations: transcriptionopathies, spliceopathies, ciliopathies, RASopathies, nuclear envelopathies and many others. 11. Disorders of sexual differentiation: Mullerian and anti-Mullerian hormones and steroids/ androgens. 12. Disorders of cardiovascular development and circulation: TBX molecular system, notch signaling pathway, sarcomere proteins, vascular endothelial growth factors and transforming growth factors. 13. Disorders of lipids: familial hypercholesterolemia, complex hyperlipidemia and other rare disorders. 14. Disorders of glycemic metabolism and regulation: Diabetes mellitus & Obesity- Mendelian and complex disorders. 15. Disorders of brain development: microcephaly, holoprosencephaly, lissencephaly and neuronal migration disorders. 16. Lysosomal and other storage disorders of the nervous system: Tay Sachs; Mucopolysaccharidoses; Gaucher's disease; Fabry's disease; Glycogen storage diseases and other rare examples. 17. Molecular basis of childhood autism, learning / intellectual difficulties and attention deficit hyperactivity disorder. 18. Disorders of ion-channels: Epilepsy and Cardiac arrhythmias. 19. Disorders of eye development, ocular structure and function; cataracts, choroidoretinal disorders and glaucoma. 20. Disorders of cranio-facial development: fibroblasts, fibroblast growth factors and fibroblast growth factor receptors. 21. Molecular basis of hearing loss: connexins and auditory neuro-receptors 22. Disorders of bone and joints: abnormal collagen- structure and function; calcium and vitamin D regulation and homeostasis. 23. Disorders of voluntary (skeletal muscle): Dystrophin, Sacroglycans and other molecular structures in muscle function. 24. Disorders of skin and appendages: Keratin and other dermal molecular structures.25. Disorders of immune function: T-cell, immunoglobins and tissue-host response. 26. Disorders of abnormal hemoglobin structure and function: sickle cell disease, beta thalassemia, alpha thalassemia, hemochromatosis and abnormal iron storage. 27. Disorders of blood groups: ABO incompatibility, Rhesus iso-sensitization and rare blood groups 28. Disorders of coagulation and bleeding: abnormal platelet structure and function; Hemophilia & van Will brand disease: rare clotting disorders. 29. Molecular basis of respiratory disorders: bronchial asthma, pulmonary failure and high altitude living. 30. Disorders of digestion and nutrition including molecular basis of inflammatory bowel disease 31. Molecular basis of inflammatory disorders (cytokines, and interferon): rheumatoid arthritis, systemic lupus erythmematosis and other disorders. 32. Molecular basis of Infectious diseases: human immunodeficiency virus (HIV), Tuberculosis, Malaria, Influenza, Oncogenic viruses, Parasites, Microbial response- susceptibility and protection, Anti-microbials and Vaccines. 33. Molecular basis of neoplasia: oncogenes, tumor suppressor genes, DNA repair and hematologic malignancies (leukemias and lymphomas) 34. Molecular basis of neuro-degenerative disorders: Huntington's disease, Spino-cerebellar ataxias, Motor Neuron Disease, Multiple sclerosis and others. 35. Molecular basis of renal and urinary structural and functional disorders 36. Molecular basis of neuro-psychiatric disorders: Depression, Bi-polar disorder, Schizophrenia, Alzheimer's and other dementia disorders (Taupathies, abnormal proteins in amyloid plaques and neurofibrillary tangles). 37. Molecular basis of ageing and apoptosis: premature aging-progenies. Section III Molecular therapeutics 38. Genomics and molecular biology applications for new drug design and development 39. Molecular basis of adverse drug reactions and favorable drug response 40. Targeted molecular therapy 41. Gene and Cell therapy including anti-sense oligonucleotide therapy 42. Stem cell and regenerative medicine 43. RNA-Interference therapy 44. Pharmacogenetics/pharmacogenomics and Personalized Medicine 45. Stratified and Precision Medicine including Nanomedicine
- ISBN: 978-0-12-809356-6
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 704
- Fecha Publicación: 01/06/2019
- Nº Volúmenes: 1
- Idioma: Inglés