The completion of the human genome project has been an important milestone inmedicine. The identifcation of approsimately 25.000 genes and their regulatory proteins provides the framwork for understanding the molecular and metabolicbasis of disease. This advance has laid the foundation for a broad range of geomic tools that have opened the way for targeted genetic testing in a number of medical disorders. INDICE: SECTION 1: GENERAL GENOMICS; 1. From Genes to Genome - a Historical Perspective; 2. The Human Genome - Structure and Organization; 3. Human Functional Genomics and Proteomics; 4. Epigenomics and Human Disease; 5. Genomic Perspectives of Human Development; 6. Genetic and Genomic Approaches to Taxonomy of Human Diseases; 7. Genomic Technologies; 8. Nutritional Genomics; 9. Pharmacogenomics: Drug Development, Drug Response and Precision Medicines; SECTION2: CLINICAL GENOMICS; 10. Clinical Medicine in the Genome Era - An Introduction; 11. Complex Cardiovascular Disorders; 12. Diabetes Mellitus and Obesity; 13. Chronic Renal Disease; 14. Haemostasis and Thrombosis; 15. Disorders of Platelets; 16. Applications in Critical Care Medicine; 17. Seizure Disorders; 18.Neurodegenerative Disorders: Tauopathies and Synucleinopathies; 19. Neuropsychiaric Diseases I: Schizophrenia; 20. Neuropsychiaric Diseases II: Mood Disorders; 21. Asthma and Chronic Obstructive Pulmonary Disease; 22. Inflammatory Bowel Disease; 23. Cancer Genomics: Mechanisms, Diagnosis and Therapeutic Implications; 24. Hematological Malignancies: The Paradigm of Acute Myeloid Leukemia; 25. Infectious Diseases: Susceptibility, Resistance, Response, and Anti-Microbial Therapy; 26. Chronic Inflammatory Disorders; 27. Immunological Disorders;28. Applications in Clinical Pediatrics; 29. Learning and Behavioural Disorders; 30. Complex Ophthalmic Disorders; 31. Applications in Audiological Medicine; 32. Complex Skin Diseases I: Psoriasis; 33. Complex Skin Diseases II: Atopic Dermatitis; 34. Complex Skin Diseases III: Diseases of the Epidermis and Appendages, Skin Pigmentation and Skin Cancer; 35. Osteoporosis and Related Disorders; 36. Applications in Obstetrics & Gynaecology and Reproductive Medicine; 37. Stem Cell Genomics, Cell-based Therapy and Regenerative Medicine; SECTION 3: HEALTH GENOMICS; 38. Genomics and Global Health; 39. Genetic Testing and Genomic Screening; 40. Ethical Issues in Human Genomics; 41. The Regulation of Human Genomics Research.
- ISBN: 978-0-19-518813-4
- Editorial: Oxford University Press
- Encuadernacion: Cartoné
- Páginas: 651
- Fecha Publicación: 01/01/2008
- Nº Volúmenes: 1
- Idioma: Inglés