Nanocarriers for Drug-Targeting Brain Tumors covers different types of nanocarriers and their design and development for targeting drugs to the brain. The book also presents case studies and the mechanism of action of nanocarriers in drug targeting to a specific site. This helps researchers and clinicians understand the design, development and mechanism of action of nanocarriers. As brain tumors continue to be a significant health problem globally, and very complex for targeting drugs, conventional dosage forms are not very effective and side-effects are a major concern. Functionalized nanocarriers can address these problems. Furthermore, the targeting of nanocarriers is preferred for reducing toxicity and improving the effectiveness of the drugs. However, there is a need for understanding the design and development of formulation with the mechanism of action of nanocarriers for brain targeting. Provides information on the design and development of nanocarriers for targeting brain tumors Outlines the working principles of different nanocarriers for targeting brain tumors Includes case studies of different nanocarriers for targeting brain tumors INDICE: Part A. Anatomy and Physiology of the Brain 1. An overview of the anatomy and physiology of brain 2. Pharmacological and clinical problems with special focus on brain tumors Part B. Pharmacological and Clinical Problems 3. Challenges in targeting to the brain and brain tumors 4. Potential targeting sites in the brain and brain tumors 5. Drug resistance problems during chemotherapy Part C. Introduction, Brain Tumor Targeting Strategies and Biomedical Applications of Nanocarriers 6. An overview on nanocarriers 7. An overview on brain tumor targeting strategies of nanocarriers 8. Biomedical applications of nanocarriers in brain tumor targeting Part D. Lipophilic Nanocarriers 9. Solid lipid nanoparticle-based drug delivery for targeting brain tumors 10. Nanostructured lipid carriers as an alternative carrier with high drug loading for targeting brain tumors 11. Design, development and mechanism of liposomes in drug targeting brain tumors 12. Niosome-based drug delivery in targeting brain tumors 13. Nanoemulsions as effective carriers for targeting brain tumors Part E. Polymeric Nanocarriers 14. Mechanism of polymeric micelles for drug targeting brain tumors 15. Dendrimers as carriers for active targeting of brain tumors 16. Multifunctional polymeric nanocarriers for the treatment of brain tumors 17. Polymersomes for targeting brain tumors Part F. Metallic Nanocarriers Systems 18. Development, mechanism and applications of gold nanoparticles for drug targeting brain tumors 19. Gold nanoparticles in cancer theranostics 20. Targeting of silver nanoparticles to brain tumors Part G. Hybrid Nanocarriers 21. Hybrid nanoparticles to cross the blood-brain barrier 22. Targeting of lipid/polymeric (hybrid) nanoparticles to brain tumors 23. Multifunctional liposome-quantum dot hybrid nanocarriers for drug targeting brain tumors 24. Tunable lipidoid-telodendrimer hybrid nanocarriers for the treatment of brain tumors Part H. Immunotherapy of Brain Tumors 25. Nano immune-conjugates in drug targeting glioblastoma 26. Nanocarriers-enabled immunotherapy for brain tumors Part I. Pharmacokinetics and Tissue Distribution Studies of Nanocarriers 27. An overview on pharmacokinetics of nanocarriers in the brain and brain tumors 28. Tracking and neuroimaging for tissue distribution studies of brain tumor targeted nanocarriers Part J. Future Directions and Toxic Concerns 29. Expert opinion on current challenges and future directions 30. Neurotoxicity issues related to nanocarriers in the treatment of brain tumors
- ISBN: 978-0-323-90773-6
- Editorial: Elsevier
- Encuadernacion: Rústica
- Páginas: 850
- Fecha Publicación: 01/06/2022
- Nº Volúmenes: 1
- Idioma: Inglés