Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immunecharacter of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspective. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits. This volume represents a collection of topics on the ‘novel’ functions of complement, patho-physiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference. Proceedings from the Fourth Aegean Conferences Workshop on Complement AssociatedDiseases, Animal Models, and Therapeutics (June 10-15, 2007) INDICE: Fromt he contents Adipokines and the Immune System: An Adipocentric View.- The Role of Complement in Stroke Therapy.- Food intake regulation by central complement system.- A Pivotal Role of Activation of Complement Cascade(CC) in Mobilization of Hematopoietic Stem/Progenitor Cells (HSPC).- Regulation of Tissue Inflammation by Thrombin-Activatable Carboxypeptidase B (or TAFI).- Interaction between the Coagulation and Complement System.- Platelet Mediated Complement Activation.-Adrenergic Regulation of Complement-induced Acute Lung Injury.- Stucture, Function and Diseases of Ficolins.- Role of Complement in Motor Neuron Disease: Animal Models and Therapeutic Potential of Complement Inhibitors.- Complement factor H - using atomic resolution structure to illuminate disease mechanisms.- The Role of Membrane Complement Regulatory Proteins in Cancer Immunotherapy .- Role of complement in ethanol-induced liver injury.
- ISBN: 978-0-387-78951-4
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 315
- Fecha Publicación: 01/08/2008
- Nº Volúmenes: 1
- Idioma: Inglés