Genetic alterations, in addition to being the fundamental drivers of tumorigenesis, give rise to a variety of adaptive metabolic changes that allow for cancer proliferation in diverse tumor microenvironments. This adaptability created a vast diversity of cancer cell metabolism which are different from the normal cellular metabolic processes common. The heterogeneity manifestations of cancer metabolism happen within the same tissue of origin, or even within individual tumor cell populations including the altered regulation of metabolic enzymes, and other biomolecules. These are often prompted and perpetuated by a variety of genetic mutations in oncogenes and tumor suppressor genes, as well as by the innate heterogeneity of the tumor microenvironment.
In this book, we delve into the complexity and diversity of cancer cell metabolism. Recognition and understanding of the heterogeneity of cancer metabolism are fundamental to the development of effective therapeutic strategies to ultimately overcome this disease. Mechanistic understanding of how cancer cells utilize a variety of fuel sources will allow for more cost-effective and personalized cancer treatment, giving a functional metabolic aspect to disease transformation, beyond traditional gene and protein profiles. Mechanistic understanding is also important for translation to clinical use as the discovery of novel metabolic biomarkers can be used to detect likely responders and non-responders to a particular chemotherapeutic agent which will enable targeted selection of patients based on predicted metabolic response.- ISBN: 978-3-319-77735-1
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 190
- Fecha Publicación: 12/08/2018
- Nº Volúmenes: 1
- Idioma: Inglés