Recent advances in genetic testing and prenatal screening have revolutionized the practice of reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. With Human Reproductive and Prenatal Genetics, editors Peter Leung and Jie Qiao have compiled the most comprehensive, practical reference title available for researchers, clinicians, and students seeking the latest applied knowledge and clinical techniques in these fields. Chapter contributions from leading scientists and clinicians provide in-depth, application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined in detail are the genetics and epigenetics of the placenta in normal and abnormal pregnancy; preimplantation genetic diagnosis and screening, with special attention to cutting-edge advances in noninvasive prenatal screening; prenatal genetic counseling; and bioethical and medicolegal aspects of relevance in the lab and clinic. This Second Edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications. Features chapter contributions from leading international scientists and clinicians Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization, placental development, embryo implantation, in vitro culture of the human embryo for the study of post-implantation development, and more Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and -omics based approaches Includes all new chapters on evolving technologies and recent genetic discoveries of relevance to reproductive medicine INDICE: Part I. Reproductive Tract Development and Gametogenesis 1. Developmental Genetics of the Male Reproductive System 2. Genetics and genomics of early gonad development 3. Genetics of Meiotic Chromosome Dynamics and Fertility 4. Effects of Aging on Sperm Chromatin 5. In Vitro Spermatogenesis from Pluripotent Stem Cells 6. Developmental Genetics of the Female Reproductive Tract 7. The Molecular Genetics of Oogenesis 8. Epigenetic Control of Oocyte Development 9. RNA Binding Protein Networks and Translational Regulation in Oocytes 10. Translational Regulation of Gene Expression during Oogenesis and Pre-implantation Embryo Development 11. MicroRNAs in Gametes and Preimplantation Embryos: Clinical Implications Part II. Embryo Implantation, Placenta Development and Pregnancy 12. Transcriptomics of the Human Endometrium and Embryo Implantation 13. Epigenetic Modifications in the Human Placenta 14. microRNAs in pregnancy: implications for basic research and clinical management 15. Chromatin Landscapes and Sex Determination 16. Genetic Alterations of Placental Development and Preeclampsia 17. Genetics and Genomics of Preterm Birth 18. The Intergenerational Effects on Fetal Programming Part III. Infertility and Assisted Reproductive Technology 19. Genetic Testing in Male Infertility 20. Genetics and Genomics of Endometriosis 21. Genetics and Genomics of Primary Ovarian Insufficiency 22. Genetics of Polycystic Ovary Syndrome 23. Genetics and Genomics of Recurrent Pregnancy Loss 24. Genetic Basis of Metabolism and Inflammation in PCOS 25. Human Genetics and Assisted Reproduction in Endometriosis Uterine Transplantation 26. Microbiota and Human Reproduction Part IV. Preimplantation/Prenatal Genetic Diagnosis and Screening 27. Epidemiology and Genetics of Human Aneuploidy 28. Next Generation Sequencing for Gene Panels and Clinical Exomes 29. Chromosomal Microarrays and Exome Sequencing for Diagnosis of Fetal Abnormalities 30. Noninvasive Prenatal Testing for Genetic Diseases 31. Emerging Planforms for Preimplantationl Genetic Testing 32. Non-Invasive Prenatal Testing by Cell-Free DNA: Technology, Biology, Clinical Utility and Limitations 33. Prenatal diagnosis and treatment of genetic steroid disorders 34. Maternal Genetic Disorders and Fetal Development 35. Genomic Sequencing for Newborn Screening 36. Implementation of Genomic Medicine in Reproductive, Prenatal and Neonatal health 37. Application of Gene-Editing Technologies in Embryos and Their Potential for Gene Therapy 38. Novel Scientific Discoveries in Reproductive and Prenatal Genetics and their Future Applications 39. Ethical Issues Related to Research on Genome Editing in Human Embryos
- ISBN: 978-0-323-91380-5
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Fecha Publicación: 01/04/2023
- Nº Volúmenes: 1
- Idioma: Inglés