Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them

Artemisinins and Antimalarial Drug Combinations: Historical and Scientific Background of Discovery and Development provides a historical and scientific background of discovery and development artemisinin, aretemisinin derivatives, combination drugs, and related chemicals. This book is a historical document, a scientific treatise, a fascinating description of innovative research on new drug development carried out under extremely difficult conditions. This book also includes detailed experiment case, physical-chemical procedures, practical methodology, and clinical trials. This book is a valuable reference work for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology, and toxicology. Presents details of all stages of drug development, including in vitro experiment, animal exploratory studies, animal tests for toxicity, safety and efficacy followed by stages I, II, III and IV, safety and efficacy in human volunteers and patients with malariaProvides many physical-chemical laboratory procedures, such as NMR, MS, HPLC and X-ray diffraction, used in drug development are described in detail for others to learn about and to replicateIncludes practical methodology of clinical trials from many research centers and countries to demonstrate the importance of this discovery INDICE: 1. Discovery of Artemisinin and History of Research and Discovery of Artemisinin Antimalarials2. Biological Research of Artemisia annua L 3. Chemical Research on Artemisinin4. Artemisinin Derivatives and Analogues5. Pharmacological Study on Artemisinin and Its Derivatives6. Clinical Studies of Artemisinin and its Derivatives7. Artemether and Lumefantrine Combination 8. Artemisinin and Naphthoquine Phosphate Combination9. The Combination of Artemisinin Drugs and Pyronaridine10. Artemisinins and piperaquine phosphate combinations

• ISBN: 978-0-12-813133-6
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 496
• Fecha Publicación: 01/11/2017
• Nº Volúmenes: 1
• Idioma: Inglés