Information gathered from cell-free systems, cell cultures, animal models, and human studies, together will provide important insights to our understandingof hormonal cancer causation, development, and prevention; the primary objective of these Symposia. A special emphasis will continue to be placed on the two major endocrine-related cancers, that is, breast and prostate. Other highly relevant cancers to be addressed are ovarian and endometrial. Emerging fields that will be examined are colon, lung, and pancreatic cancers in relation to hormones INDICE: From the contents Cellular origins of endocrine related cancers. Mitotic kinases centrosome amplification and genomic instability. New developments in steroid receptor interactions. Relevant risk assessment and early biomarkers. Novel strategies for prevention and treatment of endocrine related cancers. Hormone dependency versus hormone independency. Emerging fields: hormonesand colorectal and lung cancers. Oncogene addiction: A rationale for novel anticancer drugs and targets. What about stem cells marks. The origins of ER positive and ER negative breast cancer. PTEN, prostate cancer and HRPC development. Status of womens health. Estrogen and centrosome amplification in breast cancer. Functional significance of aurora kinase A in centrosome amplification. HPV-16 E7 and Centriole duplication. Self renewal and cancer stem cells. Role of the RIP140 co-repressor in gene network regulation.
- ISBN: 978-0-387-69078-0
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 630
- Fecha Publicación: 01/02/2008
- Nº Volúmenes: 1
- Idioma: Inglés