Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significantprogress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualizedtherapeutic strategies. This volume provides a general overview of the latestdevelopments in angiogenesis inhibition in cancer. All aspects from the benchto the bedside are considered, with detailed attention both to basic researchand to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials are presented, and variousadvanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in this exciting field. A general overview of the latest developments in angiogenesis inhibition in cancerConsiders all aspects from the bench to the bedside, with detailed attention both to basic research and to its translation into clinical practice Presents the latest results of clinical trials Discusses various advanced targeting strategies INDICE: Introduction. Angiopoietins.- HIF-1a and cancer therapy.- Chemokines.- Platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy.- Vascular integrins: therapeutic and imaging targets of tumor angiogenesis. PDGF and vessel maturation.- Lymphangiogenesis in cancer: current perspectives.- Therapeutic compounds in clinical studies of Phase III trials and beyond.- Metronomic chemotherapy – principles and lessons learned from applications in thetreatment of metastatic prostate cancer.- Targeting inflammatory cells to improve anti-VEGF therapies in oncology.- Antibody-based vascular tumor targeting. Caveolae and cancer.
- ISBN: 978-3-54078280-3
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 200
- Fecha Publicación: 15/10/2009
- Nº Volúmenes: 1
- Idioma: Inglés