This book provides a coherent, clear, and uniform presentation of structural, genetic, molecular, and biochemical information available for the zona pellucida domain protein family, which impact pathologies such as infertility, deafness, and cancer. Furthermore it: Details information about the structure and function of the ZP domain in ZPDC–proteins Provides illustrations of the organization of ZPDC–proteins, the genes that encode the proteins, and examples of mutations in the ZP domain that cause diseases Speculates as to the evolution of the ZP domain and potential therapeutics for diseases stemming from ZP domain mutations Addresses mammalian and non–mammalian systems INDICE: List of Tables Abbreviations Preface Part A. Zona Pellucida Domain Proteins A.1 Nature of the ZPD A.2 Mouse ZP Proteins A.3 Synthesis, Secretion, and Assembly of ZP Proteins A.4 Structure of the ZPD A.5 Evolution of ZPD Proteins Part B. Mammalian Zona Pellucida Proteins B.1 Introduction B.2 Monotremes – Platypus (O. anatinus) – ZP1–4 B.3 Marsupials – Brushtail Possum (T. vulpecula) – ZP2–4 B.4 Placental Mammals B.5 Mammalian ZP Proteins as Anti–Fertility Vaccines B.6 Summary Tables Part C. Mammalian Zona Pellucida Domain Proteins C.1 Betaglycan/TGF Receptor Type III C.2 Cub and Zona Pellucida–like Domain 1 (CUZD–1) Proteins C.3 Deleted in Malignant Brain Tumor 1 (DMBT1) Proteins C.4 Endoglin/CD–105 C.5 Liver–Specific ZPD–Containing Protein (LZP) C.6 Oocyte–Secreted Protein 1 (Oosp1) C.7 Pancreatic Zymogen Granule Protein (GP–2) C.8 Placenta–Specific 1 (Plac1) C.9 Tectorin– and – C.10 Uromodulin/Tamm–Horsfall Protein C.11 Uromodulin–like Proteins C.12 Summary Tables Part D. Non–Mammalian Zona Pellucida Domain Proteins D.1 Jellyfish (A. aurata) D.2 Sea Urchins (S. purpuratus) D.3 Nematodes (C. elegans) D.4 Molluscs (H. rufescens) D.5 Fruit Flies (D. melanogaster) D.6 Tunicates – Vitelline Coat Proteins and Oikosins D.7 Fish – Vitelline Envelope Proteins D.8 Amphibians – Vitelline Envelope Proteins D.9 Reptiles – Predicted ZPD Proteins D.10 Birds – Vitelline Envelope Proteins D.11 Summary Tables Part E. Appendix E.1 Sources of Sequence Information E.2 Site(s) of ZP Protein Synthesis E.3 Characteristics of Mammalian and Non–Mammalian ZPD Proteins E.4 Comparison of Vertebrate ZP Proteins with Human ZP1–4 E.5A and E.5B Sequence Alignments of ZPDs with 11 Cys Residues
- ISBN: 978-0-470-52811-2
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 250
- Fecha Publicación: 13/07/2015
- Nº Volúmenes: 1
- Idioma: Inglés