This volume will discuss all important aspects of RNase P structure and function in eukaryotic, prokaryotic, and viral systems. It will cover a broad rangeof subjects in RNA research, including: structural analysis by biochemical orbiophysical means; mRNA structure, function and biogenesis; ribosome structure and function; translational control; and RNA catalysis. RNA and RNase is an interdisciplinary topic that represents molecular, evolutionary and structuralbiology, biochemistry, biomedical sciences, chemistry, genetics, and virologyas they relate to questions of the structure and function of RNA and of ribonucleoprotein assemblies." "Will cover a broad range of subjects in RNA research, including: structural analysis by biochemical or biophysical means; mRNA structure, function and biogenesis; ribosome structure and function; translational control; and RNA catalysis INDICE: History of RNase P and overview of its catalytic activity.- The Evolution of RNase P and its RNA.- Structure Modeling of RNase P.- Structural studies of RNase P.- Folding of bacterial RNase P RNA.- Kinetic Mechanism of Bacterial RNase P.- Roles of metal ions in RNase P catalysis.- Challenges in RNase P Substrate Recognition: Considering the Biological Context.- Archaeal RNaseP: A Mosaic Of Its Bacterial And Eukaryal Relatives.- Eukaryote RNase P and RNase MRP.- RNase P From Organelles.- Human RNase P and transcription.- RNase Pas a drug target.- Ribonuclease P as a Tool.
- ISBN: 978-1-4419-1141-4
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 600
- Fecha Publicación: 01/12/2009
- Nº Volúmenes: 1
- Idioma: Inglés